<i>In vivo</i> evaluation of focused ultrasound ablation surgery (FUAS)-induced coagulation using echo amplitudes of the therapeutic focused ultrasound transducer

作者全名："Zhou, Yufeng; Gong, Xiaobo; You, Yaqing"

作者地址："[Zhou, Yufeng] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Zhou, Yufeng] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China; [Zhou, Yufeng] Natl Med Prod Adm NMPA, Key Lab Qual Evaluat Ultrason Surg Equipment, Wuhan, Hubei, Peoples R China; [Gong, Xiaobo; You, Yaqing] Natl Engn Res Ctr Ultrasound Med, Res & Dev, Chongqing, Peoples R China; [Zhou, Yufeng] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Med Coll Rd, Chongqing, Peoples R China"

通信作者："Zhou, YF (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China.; Zhou, YF (通讯作者)，Natl Med Prod Adm NMPA, Key Lab Qual Evaluat Ultrason Surg Equipment, Wuhan, Hubei, Peoples R China.; Zhou, YF (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Med Coll Rd, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001180359700001

JCR分区：Q2

影响因子：3.1

年份：2024

卷号：41

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Focused ultrasound ablation surgery FUAS; coagulative necrosis; echo amplitude; focused ultrasound (FUS) transducer; sonography; coagulation prediction

摘要："Objective: Monitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in similar to 50% of successful coagulation in uterine fibroids). A more accurate and sensitive approach is required. Method: The echo amplitudes of the focused ultrasound (FUS) transducer in a testing mode (short pulse duration and low power) were found to correlate with the ex vivo coagulation. To further evaluate its coagulation prediction capabilities, in vivo experiments were carried out. The liver, kidney, and leg muscles of three adult goats were treated using clinical FUAS settings, and the echo amplitude of the FUS transducer and grayscale in sonography before and after FUAS were collected. On day 7, animals were sacrificed humanely, and the treated tissues were dissected to expose the lesion. Echo amplitude changes and lesion areas were analyzed statistically, as were the coagulation prediction metrics. Results: The echo amplitude changes of the FUS transducer correlate well with the lesion areas in the liver (R = 0.682). Its prediction in accuracy (94.4% vs. 50%), sensitivity (92.9% vs. 35.7%), and negative prediction (80% vs. 30.8%) is better than sonography, but similar in specificity (80% vs. 100%) and positive prediction (100% vs. 100%). In addition, the correlation between tissue depth and the lesion area is not good (|R| < 0.2). Prediction performances in kidney and leg muscles are similar. Conclusion: The FUS echo amplitudes are sensitive to the tissue properties and their changes after FUAS. They are sensitive and reliable in evaluating and predicting FUAS outcomes."

基金机构：Future Innovative Research Fund of Chongqing Medical University [2022-W0063]

基金资助正文：This work was supported by the Future Innovative Research Fund of Chongqing Medical University (2022-W0063).