Comparison of Computed Tomography and Clinical Features Between Patients Infected with the SARS-CoV-2 Omicron Variant and the Original Strain

作者全名："Zhang, Yue; Li, Qi; Xiang, Jiang-Lin; Li, Xing-Hua; Li, Jing"

作者地址："[Zhang, Yue; Li, Qi; Li, Xing-Hua] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China; [Xiang, Jiang-Lin] Chongqing Univ, Dept Infect Dis, Three Gorges Hosp, Chongqing 404000, Peoples R China; [Li, Jing] Liangjiang New Area Renhe Community Hlth Serv Ctr, Med Dept, Chongqing 401147, Peoples R China"

通信作者："Li, XH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China.; Li, J (通讯作者)，Liangjiang New Area Renhe Community Hlth Serv Ctr, Med Dept, Chongqing 401147, Peoples R China."

来源：INFECTION AND DRUG RESISTANCE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001180496600001

JCR分区：Q2

影响因子：3.9

年份：2024

卷号：17

期号：　

开始页：807

结束页：818

文献类型：Article

关键词：severe acute respiratory syndrome coronavirus-2; pneumonia; computed tomography

摘要："Purpose: To investigate potential differences in clinical and computed tomography (CT) features between patients with the SARSCoV-2 Omicron variant and the original strain. Patients and Methods: This retrospective study included 69 hospitalized patients infected with Omicron variant from November to December 2022, and 96 hospitalized patients infected with the original strain from February to March 2020 in Chongqing, China. The clinical features, CT manifestations, degrees of lung involvement in different stages on CT, and imaging changes after the reversetranscription polymerase chain reaction (RT-PCR) results turned negative were compared between the two groups. Results: For clinical features, patients with Omicron were predominantly old people and females, without manifestation of any clinical symptoms, who had low serum levels of C -reactive protein and procalcitonin. Shorter interval from symptoms onset to initial CT scan was observed in Omicron patients compared to patients with the original strain (all P < 0.05). For CT features, patients with Omicron were more likely to present with round -like opacities and tree -in -bud pattern (all P < 0.05), but less likely to exhibit a diffuse distribution, patchy and linear opacities, as well as vascular enlargement pattern (all P < 0.05). The Omicron group was more susceptible to exhibiting lower CT involvement scores in each stage (all P < 0.05) and imaging progression after the RT-PCR results turned negative (P < 0.001). Conclusion: Patients infected with the Omicron variant exhibited less severe changes on chest CT compared to those infected with the original strain. Furthermore, imaging progression under low viral load conditions was more common in patients with Omicron than in those with the original strain."

基金机构：Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2022MSXM147]; Chongqing Health Commission (Chongqing Talent Program-Innovation leading Talent Research Project) of China [CQYC20210303348]

基金资助正文：This study was supported by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2022MSXM147) and Chongqing Health Commission (Chongqing Talent Program-Innovation leading Talent Research Project) (CQYC20210303348) of China.