Catalysts of Healing: A Symphony of Synthesis and Clinical Artistry in Small-Molecule Agents for Breast Cancer Alleviation

作者全名："Hu, Jing; Zhu, Bi-Yue; Niu, Zhen-Xi"

作者地址："[Hu, Jing; Niu, Zhen-Xi] Zhengzhou Univ, Henan Childrens Hosp, Zhengzhou Childrens Hosp, Childrens Hosp, Zhengzhou 450018, Peoples R China; [Zhu, Bi-Yue] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Boston, MA 02129 USA; [Zhu, Bi-Yue] Harvard Med Sch, Boston, MA 02129 USA; [Zhu, Bi-Yue] Chongqing Med Univ, Dept Pharm, Childrens Hosp, Chongqing 400015, Peoples R China"

通信作者："Niu, ZX (通讯作者)，Zhengzhou Univ, Henan Childrens Hosp, Zhengzhou Childrens Hosp, Childrens Hosp, Zhengzhou 450018, Peoples R China.; Zhu, BY (通讯作者)，Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Boston, MA 02129 USA.; Zhu, BY (通讯作者)，Harvard Med Sch, Boston, MA 02129 USA.; Zhu, BY (通讯作者)，Chongqing Med Univ, Dept Pharm, Childrens Hosp, Chongqing 400015, Peoples R China."

来源：MOLECULES

ESI学科分类：CHEMISTRY

WOS号：WOS:001183114200001

JCR分区：Q2

影响因子：4.6

年份：2024

卷号：29

期号：5

开始页：　

结束页：　

文献类型：Review

关键词：breast cancer; small-molecule drugs; synthetic pathways; clinical applications

摘要："Breast cancer, characterized by its molecular intricacy, has witnessed a surge in targeted therapeutics owing to the rise of small-molecule drugs. These entities, derived from cutting-edge synthetic routes, often encompassing multistage reactions and chiral synthesis, target a spectrum of oncogenic pathways. Their mechanisms of action range from modulating hormone receptor signaling and inhibiting kinase activity, to impeding DNA damage repair mechanisms. Clinical applications of these drugs have resulted in enhanced patient survival rates, reduction in disease recurrence, and improved overall therapeutic indices. Notably, certain molecules have showcased efficacy in drug-resistant breast cancer phenotypes, highlighting their potential in addressing treatment challenges. The evolution and approval of small-molecule drugs have ushered in a new era for breast cancer therapeutics. Their tailored synthetic pathways and defined mechanisms of action have augmented the precision and efficacy of treatment regimens, paving the way for improved patient outcomes in the face of this pervasive malignancy. The present review embarks on a detailed exploration of small-molecule drugs that have secured regulatory approval for breast cancer treatment, emphasizing their clinical applications, synthetic pathways, and distinct mechanisms of action."

基金机构：Joint Construction Project of Henan Provincial Medical Science and Technology Key Program

基金资助正文：No Statement Available