Regulation of rheumatoid arthritis microenvironment via a self-healing injectable hydrogel for improved inflammation elimination and bone repair

作者全名："Geng, Wenbo; Zhao, Jie; Tao, Bailong; Yang, Yulu; Duan, Qiaojian; Gao, Pengfei; He, Tingting; Liu, Shaopeng; Feng, Qian; Zhao, Peng; Cai, Kaiyong"

作者地址："[Geng, Wenbo; Yang, Yulu; Duan, Qiaojian; Gao, Pengfei; He, Tingting; Liu, Shaopeng; Feng, Qian; Zhao, Peng; Cai, Kaiyong] Chongqing Univ, Minist Educ, Key Lab Biorheol Sci & Technol, Coll Bioengn, Chongqing 400044, Peoples R China; [Zhao, Jie] Chengdu Univ Tradit Chinese Med, Coll Med & Life Sci, Chengdu 611137, Sichuan, Peoples R China; [Tao, Bailong] Chongqing Med Univ, Lab Res Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Zhao, P; Cai, KY (通讯作者)，Chongqing Univ, Minist Educ, Key Lab Biorheol Sci & Technol, Coll Bioengn, Chongqing 400044, Peoples R China."

来源：BIOACTIVE MATERIALS

ESI学科分类：　

WOS号：WOS:001189045800001

JCR分区：Q1

影响因子：18.9

年份：2024

卷号：36

期号：　

开始页：287

结束页：300

文献类型：Article

关键词：Microenvironment; Hydrogels; Rheumatoid arthritis; Nitric oxide; Hydrogen sulfide

摘要："The rheumatoid arthritis (RA) microenvironment is often followed by a vicious circle of high inflammation, endogenous gas levels imbalance, and poor treatment. To break the circle, we develop a dual-gas-mediated injectable hydrogel for modulating the immune microenvironment of RA and simultaneously releasing therapeutic drugs. The hydrogel (DNRS gel) could be broken down on-demand by consuming excessive nitric oxide (NO) and releasing therapeutic hydrogen sulfide (H2S), resulting in endogenous gas restoration, inflammation alleviation, and macrophage polarization to M2 type. Additionally, the hydrogel could suppress osteoclastogenesis and enhance osteogenesis. Furthermore, the intra-articularly injected hydrogel with methotrexate (MTX/ DNRS gel) significantly alleviated inflammation and clinical symptoms and promoted the repair of bone erosion in the collagen-induced arthritis rat model. As a result, in vivo results demonstrated that MTX/DNRS gel restored the microenvironment and improved the therapeutic effect of MTX. This study provides a novel understanding of developing versatile smart delivery platforms for RA treatment."

基金机构："National Key Research and Development Program of China [2022YFB3804400]; National Natural Science Foundation of China [52333011, 82102225]; Venture & Innovation Support Program for Chongqing Overseas Returnees [cx2023104]; Natural Science Foundation of Chongqing [cstc2021jcyj-cxttX0002]"

基金资助正文："This work was financially supported by National Key Research and Development Program of China (2022YFB3804400) , National Natural Science Foundation of China (52333011, and 82102225) , Venture & Innovation Support Program for Chongqing Overseas Returnees (cx2023104) , and Natural Science Foundation of Chongqing (cstc2021jcyj-cxttX0002) ."