The role of proteasomes in tumorigenesis

作者全名："Zhou, Xiangyi; Xu, Ruqing; Wu, Yue; Zhou, Li; Xiang, Tingxiu"

作者地址："[Zhou, Xiangyi; Xu, Ruqing; Wu, Yue; Xiang, Tingxiu] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Zhou, Xiangyi; Zhou, Li; Xiang, Tingxiu] Chongqing Univ, Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis & I, Chongqing 400030, Peoples R China"

通信作者："Xiang, TX (通讯作者)，Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Zhou, L; Xiang, TX (通讯作者)，Chongqing Univ, Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis & I, Chongqing 400030, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001189167800001

JCR分区：Q1

影响因子：6.8

年份：2024

卷号：11

期号：4

开始页：　

结束页：　

文献类型：Review

关键词：Bortezomib; Cancer therapy; Multiple myeloma; Proteasome 20S; Proteasome inhibitor; Thymoproteasom

摘要："Protein homeostasis is the basis of normal life activities, and the proteasome family plays an extremely important function in this process. The proteasome 20S is a concentric circle structure with two a rings and two 0 rings overlapped. The proteasome 20S can perform both ATP-dependent and non-ATP-dependent ubiquitination proteasome degradation by binding to various subunits (such as 19S, 11S, and 200 PA), which is performed by its active subunit 01, 02, and 05. The proteasome can degrade misfolded, excess proteins to maintain homeostasis. At the same time, it can be utilized by tumors to degrade over-proliferate and unwanted proteins to support their growth. Proteasomes can affect the development of tumors from several aspects including tumor signaling pathways such as NF-xB and p53, cell cycle, immune regulation, and drug resistance. Proteasome-encoding genes have been found to be overexpressed in a variety of tumors, providing a potential novel target for cancer therapy. In addition, proteasome inhibitors such as bortezomib, carfilzomib, and ixazomib have been put into clinical application as the first-line treatment of multiple myeloma. More and more studies have shown that it also has different therapeutic effects in other tumors such as hepatocellular carcinoma, non-small cell lung cancer, glioblastoma, and neuroblastoma. However, proteasome inhibitors are not much effective due to their tolerance and singleness in other tumors. Therefore, further studies on their mechanisms of action and drug interactions are needed to investigate their therapeutic potential. (c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/)."

基金机构："National Natural Science Foundation of China [82172619]; Natural Science Foundation of Chongqing, China [CSTC2021jscx-gksb- N0023]; Medical and Industrial Integration Project (China) [2022CDJYGRH-002]"

基金资助正文："<BOLD>Funding</BOLD> This study was supported by the National Natural Science Foundation of China (No. 82172619) , the Natural Science Foundation of Chongqing, China (No. CSTC2021jscx-gksb- N0023) , and the Medical and Industrial Integration Project (China) (No. 2022CDJYGRH-002) ."