Pillar[6]MaxQ functions as an <i>in vivo</i> sequestrant for rocuronium and vecuronium
作者全名："Zhang, Wanping; Bazan-Bergamino, Emmanuel A.; Doan, Anton P.; Zhang, Xiangjun; Isaacs, Lyle"
作者地址："[Zhang, Wanping; Zhang, Xiangjun] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Bazan-Bergamino, Emmanuel A.; Doan, Anton P.; Isaacs, Lyle] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA"
通信作者："Zhang, XJ (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China.; Isaacs, L (通讯作者)，Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA."
来源：CHEMICAL COMMUNICATIONS
ESI学科分类：CHEMISTRY
WOS号：WOS:001193216100001
JCR分区：Q2
影响因子：4.9
年份：2024
卷号：60
期号：32
开始页：4350
结束页：4353
文献类型：Article
关键词：
摘要：The binding affinity of pillar[6]MaxQ toward a panel of neuromuscular blockers and neurotransmitters was measured in phosphate buffered saline by isothermal titration calorimetry and 1H NMR spectroscopy. In vivo efficacy studies showed that P6MQ sequesters rocuronium and vecuronium and reverses their influence on the recovery of the train-of-four (TOF) ratio.
基金机构：University of Maryland; Chongqing Medical University
基金资助正文："L. I., E. A. B.-B., and A. P. D. thank the University of Maryland for financial support. X. Z. and W. Z. thank the Chongqing Medical University for financial support"
