Systematic review of metabolomic alterations in ulcerative colitis: unveiling key metabolic signatures and pathways
作者全名:"Liu, Meiling; Guo, Siyi; Wang, Liang"
作者地址:"[Liu, Meiling] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Guo, Siyi; Wang, Liang] Chongqing Med Univ, Chongqing, Peoples R China"
通信作者:"Liu, ML (通讯作者),Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."
来源:THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
ESI学科分类:CLINICAL MEDICINE
WOS号:WOS:001193627600001
JCR分区:Q1
影响因子:3.9
年份:2024
卷号:17
期号:
开始页:
结束页:
文献类型:Review
关键词:metabolites; metabolomics; pathway analysis; ulcerative colitis
摘要:"Background: Despite numerous metabolomic studies on ulcerative colitis (UC), the results have been highly variable, making it challenging to identify key metabolic abnormalities in UC.Objectives: This study aims to uncover key metabolites and metabolic pathways in UC by analyzing existing metabolomics data.Design: A systematic review.Data sources and methods: We conducted a comprehensive search in databases (PubMed, Cochrane Library, Embase, and Web of Science) and relevant study references for metabolomic research on UC up to 28 December 2022. Significant metabolite differences between UC patients and controls were identified, followed by an analysis of relevant metabolic pathways.Results: This review incorporated 78 studies, identifying 2868 differentially expressed metabolites between UC patients and controls. The metabolites were predominantly from 'lipids and lipid-like molecules' and 'organic acids and derivatives' superclasses. We found 101 metabolites consistently altered in multiple datasets within the same sample type and 78 metabolites common across different sample types. Of these, 62 metabolites exhibited consistent regulatory trends across various datasets or sample types. Pathway analysis revealed 22 significantly altered metabolic pathways, with 6 pathways being recurrently enriched across different sample types.Conclusion: This study elucidates key metabolic characteristics in UC, offering insights into molecular mechanisms and biomarker discovery for the disease. Future research could focus on validating these findings and exploring their clinical applications."
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