Exploring Risk Factors for Early Pregnancy Loss: A Retrospective Hysteroscopy Study in a Single Institution

作者全名："Cao, Chaoxia; Liu, Xiaoli; Chen, Yinan; Yang, Xiujun; Peng, Bin; Hu, Zhouying; Zhou, Qin"

作者地址："[Cao, Chaoxia; Liu, Xiaoli] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Cao, Chaoxia; Liu, Xiaoli] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China; [Cao, Chaoxia; Liu, Xiaoli] Chongqing Res Ctr Prevent & Control Maternal & Chi, Chongqing 401147, Peoples R China; [Chen, Yinan] UCL, Sch Math & Phys, Dept Math, London WC1E 6AE, England; [Yang, Xiujun; Hu, Zhouying; Zhou, Qin] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing 400016, Peoples R China; [Peng, Bin] Chongqing Med Univ, Sch Publ Hlth, Dept Hlth Stat, Chongqing 400016, Peoples R China"

通信作者："Zhou, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing 400016, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001194055900008

JCR分区：Q4

影响因子：0.2

年份：2024

卷号：51

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：early pregnancy loss; hysteroscopy; intrauterine adhesion; risk factors

摘要："Background: To explore the risk factors for early pregnancy loss and to study the relationship between early pregnancy loss and intrauterine adhesion (IUA) confirmed by hysteroscopy. Methods: A retrospective study was conducted on 226 early pregnancy loss and 51 early pregnancy patients who received medical management combined with hysteroscopy at a regional institution from March 2020 to February 2021. The uterine cavity's shape was evaluated by hysteroscopy 6 hours after treatment with medicine. Risk factors included maternal age, gestational weeks, gravidity, parity, number of prior early pregnancy losses, number of prior induced abortions, mean sac diameter (MSD) and IUA. Results: Our results showed that the prevalence of IUA increased significantly in early pregnancy loss cases (31.42%) compared with early pregnancy cases (9.8%) (p << 0.01). Multivariate logistic regression analysis showed that maternal age (odds ratio (OR): 1.195, 95% confidence interval (95% CI): 1.077-1.326), gestational weeks (OR: 2.919, 95% CI: 2.028-4.201) and IUA (OR: 8.631, 95% CI: 2.455-30.336) were positively associated with early pregnancy loss, while MSD (OR: 0.943, 95% CI: 0.899-0.990) and parity (OR: 0.194, 95% CI: 0.088-0.428) were inversely associated with early pregnancy loss. Conclusions: Maternal age, gestational weeks and, IUA were the risk factors for early pregnancy loss. Special attention is to be given to cases of combined IUA when managing early pregnancy loss."

基金机构：Department of Obstetrics and Gynecology; First Affiliated Hospital of Chongqing Medical University

基金资助正文："We greatly appreciate the support from the colleagues in Department of Obstetrics and Gynecology, the First Affiliated Hospital of Chongqing Medical University."