The alleviating effect of<i> Akkermansia</i><i> muciniphila</i> PROBIO on AOM/ DSS-induced colorectal cancer in mice and its regulatory effect on gut microbiota

作者全名："Ma, Xin; Yan, Lvjun; Yu, Xueping; Guo, Hui; He, Yongpeng; Wen, Shufan; Yu, Ting; Wang, Wei"

作者地址："[Ma, Xin; Yu, Xueping; Wang, Wei] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China; [Yan, Lvjun] Chongqing Med Univ, Univ Town Hosp, Tumor & Hematol Dept, Chongqing 401331, Peoples R China; [Guo, Hui; Wen, Shufan; Yu, Ting] Chongqing Univ Educ, Collaborat Innovat Ctr Child Nutr & Hlth Dev, Chongqing Engn Res Ctr Funct Food, Chongqing Engn Lab Res & Dev Funct Food, Chongqing 400067, Peoples R China; [He, Yongpeng] Chongqing Univ, Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis &, Chongqing 400030, Peoples R China; [He, Yongpeng] Chongqing Canc Inst, Chongqing 400030, Peoples R China; [He, Yongpeng] Chongqing Canc Hosp, Chongqing 400030, Peoples R China"

通信作者："Wang, W (通讯作者)，East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.; Yu, T (通讯作者)，Chongqing Univ Educ, Collaborat Innovat Ctr Child Nutr & Hlth Dev, Chongqing Engn Res Ctr Funct Food, Chongqing Engn Lab Res & Dev Funct Food, Chongqing 400067, Peoples R China."

来源：JOURNAL OF FUNCTIONAL FOODS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001194191300001

JCR分区：Q1

影响因子：5.6

年份：2024

卷号：114

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Akkermansia muciniphila; AOM/DSS; Inflammation-associated colorectal cancer; NF-kappa B; Apoptosis

摘要："Emerging evidence indicates that Akkermansia muciniphila (AKK) may be a potential probiotic agent for ameliorating colorectal cancer (CRC). Thus, we utilized the azoxymethane (AOM)/ dextran sodium sulfate (DSS)induced mouse model of colorectal cancer to evaluate the intervention effect of AKK PROBIO. The results showed that AKK PROBIO significantly improved mouse colon health, decreased the serum pro-inflammatory cytokines levels, as well as downregulated the mRNA levels of p50, p52, p65, and I kappa B beta, upregulated the expressions of Bid, Bim, and caspase-9 in the colon. In addition, AKK PROBIO modulated the gut microbiota composition, as characterized by the increased abundance of Muribaculaceae and Akkermansia and the decreased levels of Bacteroides, and Parasutterella. Notably, the high-dosage group was better than that of low-dosage. In conclusion, AKK PROBIO has the potential to modulate colorectal cancer by alleviating intestinal inflammation through the NF-kappa B pathway and promoting cell apoptosis, thereby intervening in the development of colorectal tumors."

基金机构：Suzhou Social Development Science and Technology Innovation Project [2022SS35]; Scientific research project of Chongqing Medical Biotechnology Association [cmba2022kyym- zkxmQ0012]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-BHX0024]

基金资助正文：<BOLD>Funding</BOLD> This work was supported by Suzhou Social Development Science and Technology Innovation Project (2022SS35) ; Scientific research project of Chongqing Medical Biotechnology Association (NO. cmba2022kyym- zkxmQ0012) ; Natural Science Foundation of Chongqing (NO. CSTB2022NSCQ-BHX0024) .