Spinal cord and brain atrophy patterns in neuromyelitis optica spectrum disorder and multiple sclerosis

作者全名："Hua, Tiantian; Fan, Houyou; Duan, Yunyun; Tian, Decai; Chen, Zhenpeng; Xu, Xiaolu; Bai, Yutong; Li, Yuna; Zhang, Ningnannan; Sun, Jie; Li, Haiqing; Li, Yuxin; Li, Yongmei; Zeng, Chun; Han, Xuemei; Zhou, Fuqing; Huang, Muhua; Xu, Siyao; Jin, Ying; Li, Hongfang; Zhuo, Zhizheng; Zhang, Xinghu; Liu, Yaou"

作者地址："[Hua, Tiantian; Duan, Yunyun; Xu, Xiaolu; Li, Yuna; Xu, Siyao; Jin, Ying; Li, Hongfang; Zhuo, Zhizheng; Liu, Yaou] Beijing Tiantan Hosp, Dept Radiol, 119 South 4th Ring West Rd, Beijing 100070, Peoples R China; [Fan, Houyou; Bai, Yutong] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China; [Tian, Decai; Zhang, Xinghu] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100070, Peoples R China; [Chen, Zhenpeng] Capital Med Univ, Sch Biomed Engn, Beijing Key Lab Fundamental Res Biomech Clin Appli, Beijing, Peoples R China; [Zhang, Ningnannan; Sun, Jie] Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China; [Zhang, Ningnannan; Sun, Jie] Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China; [Li, Haiqing; Li, Yuxin] Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai, Peoples R China; [Li, Yongmei; Zeng, Chun] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Han, Xuemei] Jilin Univ, Dept Neurol, China Japan Union Hosp, Changchun, Peoples R China; [Zhou, Fuqing; Huang, Muhua] Nanchang Univ, Affiliated Hosp 1, Dept Radiol, Nanchang, Peoples R China"

通信作者："Liu, YU (通讯作者)，Beijing Tiantan Hosp, Dept Radiol, 119 South 4th Ring West Rd, Beijing 100070, Peoples R China."

来源：JOURNAL OF NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001194897600001

JCR分区：Q1

影响因子：6

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Neuromyelitis optica spectrum disorder; Multiple sclerosis; Atrophy pattern; Non-negative matrix factorization

摘要："BackgroundSpinal cord and brain atrophy are common in neuromyelitis optica spectrum disorder (NMOSD) and relapsing-remitting multiple sclerosis (RRMS) but harbor distinct patterns accounting for disability and cognitive impairment.MethodsThis study included 209 NMOSD and 304 RRMS patients and 436 healthy controls. Non-negative matrix factorization was used to parse differences in spinal cord and brain atrophy at subject level into distinct patterns based on structural MRI. The weights of patterns were obtained using a linear regression model and associated with Expanded Disability Status Scale (EDSS) and cognitive scores. Additionally, patients were divided into cognitive impairment (CI) and cognitive preservation (CP) groups.ResultsThree patterns were observed in NMOSD: (1) Spinal Cord-Deep Grey Matter (SC-DGM) pattern was associated with high EDSS scores and decline of visuospatial memory function; (2) Frontal-Temporal pattern was associated with decline of language learning function; and (3) Cerebellum-Brainstem pattern had no observed association. Patients with CI had higher weights of SC-DGM pattern than CP group. Three patterns were observed in RRMS: (1) DGM pattern was associated with high EDSS scores, decreased information processing speed, and decreased language learning and visuospatial memory functions; (2) Frontal-Temporal pattern was associated with overall cognitive decline; and (3) Occipital pattern had no observed association. Patients with CI trended to have higher weights of DGM and Frontal-Temporal patterns than CP group.ConclusionThis study estimated the heterogeneity of spinal cord and brain atrophy patterns in NMOSD and RRMS patients at individual level, and evaluated the clinical relevance of these patterns, which may contribute to stratifying participants for targeted therapy."

基金机构：National Science Foundation of China

基金资助正文：We acknowledge the contribution of colleagues and patients who participated in this multicenter study.