Prognostic Value of Postoperative Complication for Gastric Cancer

作者全名："Ren, Lin-Fei; Xu, Yong-Hong; Long, Jie-Gen"

作者地址："[Ren, Lin-Fei; Xu, Yong-Hong; Long, Jie-Gen] Chongqing Med Univ, Affiliated Banan Hosp, Dept Gen Surg, Chongqing, Peoples R China; [Long, Jie-Gen] Chongqing Med Univ, Affiliated Banan Hosp, Dept Gen Surg, 12-54 Xinnong St, Chongqing 401320, Peoples R China"

通信作者："Long, JG (通讯作者)，Chongqing Med Univ, Affiliated Banan Hosp, Dept Gen Surg, 12-54 Xinnong St, Chongqing 401320, Peoples R China."

来源：JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001196752600003

JCR分区：Q3

影响因子：1.3

年份：2024

卷号：34

期号：4

开始页：339

结束页：353

文献类型：Article

关键词：gastric cancer; complication; prognosis; surgery

摘要："Background: The incidence of complications in gastric cancer (GC) patients after surgery was increasing, and it was not clear whether postoperative complications would have an impact on prognosis. The current study attempted to investigate the role of postoperative complication for prognosis on GC patients undergoing radical resection. Materials and Methods: Eligible studies were searched in three databases, including PubMed, Embase, and the Cochrane Library, in accordance with the searching strategy on September 4th, 2022. The survival values were most concerned; then, hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled up. All prognostic values, including overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and recurrence-free survival (RFS), were allowed. Subgroup analysis based on complication types was used for further in-depth research. Results: A total of 29 studies involving 33,858 patients were included in this study. Intra-abdominal abscess (19.4%) was the most common complications in the included studies, followed by anastomotic leakage (17.0%) and pneumonia (16.4%). There were 23, 4, 6, and 10 studies that reported OS, DFS, DSS, and RFS, respectively. After analysis, postoperative complication was found to be an independent prognostic factor for OS (HR = 1.52, I2 = 1.14%, 95% CI = 1.42-1.61, P = .00), DFS (HR = 1.71, I2 = 0.00%,95% CI = 1.44-1.98, P < .05), DSS (HR = 1.60, I2 = 54.58%, 95% CI = 1.26-1.93, P < .1), and RFS (HR = 1.26, I2 = 0.00%, 95% CI = 1.11-1.41, P < .05). Subgroup analysis found that noninfectious complication was not significantly associated with OS (HR = 1.39, I2 = 0.00%, 95% CI = 0.96-1.82, P > .05). Conclusion: Surgeons needed to pay more attention to GC patients who developed postoperative complications, especially infectious complications, and take proactive management to improve the prognosis."

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