Crosstalk between metabolism and cell death in tumorigenesis

作者全名："Yang, Shichao; Hu, Caden; Chen, Xiaomei; Tang, Yi; Li, Juanjuan; Yang, Hanqing; Yang, Yi; Ying, Binwu; Xiao, Xue; Li, Shang-Ze; Gu, Li; Zhu, Yahui"

作者地址："[Yang, Shichao; Hu, Caden; Chen, Xiaomei; Yang, Hanqing; Li, Shang-Ze; Zhu, Yahui] Chongqing Univ, Sch Med, Chongqing 400030, Peoples R China; [Tang, Yi] Chongqing Med Univ, Mol Med Diagnost & Testing Ctr, Chongqing, Peoples R China; [Tang, Yi] Chongqing Med Univ, Coll Basic Med, Dept Pathol, Chongqing, Peoples R China; [Li, Juanjuan] Wuhan Univ, Dept Breast & Thyroid Surg, Renmin Hosp, Wuhan 430060, Peoples R China; [Yang, Yi] Army Med Univ, Affiliated Hosp 1, Key Lab Tumor Immunopathol, Inst Pathol,Mil Med Univ 3,Minist Educ China, Chongqing 400038, Peoples R China; [Tang, Yi] Army Med Univ, Southwest Canc Ctr, Minist Educ China, Mil Med Univ 3, Chongqing 400038, Peoples R China; [Ying, Binwu; Gu, Li] Sichuan Univ, West China Hosp, Clin Lab Med Res Ctr, Dept Lab Med, Chengdu 610041, Sichuan, Peoples R China; [Xiao, Xue] Sichuan Univ, West China Univ Hosp 2, Dept Gynecol & Obstet, Chengdu, Peoples R China; [Xiao, Xue] Sichuan Univ, West China Hosp 2, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China"

通信作者："Li, S-; Zhu, YH (通讯作者)，Chongqing Univ, Sch Med, Chongqing 400030, Peoples R China.; Ying, BW; Gu, L (通讯作者)，Sichuan Univ, West China Hosp, Clin Lab Med Res Ctr, Dept Lab Med, Chengdu 610041, Sichuan, Peoples R China.; Xiao, X (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Gynecol & Obstet, Chengdu, Peoples R China.; Xiao, X (通讯作者)，Sichuan Univ, West China Hosp 2, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China."

来源：MOLECULAR CANCER

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001197174000001

JCR分区：Q1

影响因子：37.3

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Tumor metabolism; Cell death; Apoptosis; Pyroptosis; Ferroptosis; Cuproptosis; Autophage; Tumor microenvironment

摘要："It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy their growth needs and resist adverse environmental events, tumor cells modify the metabolic pathways to produce both extra energies and substances required for rapid growth. Realizing the metabolic characters special for tumor cells will be helpful for eliminating them during therapy. Cell death is a hot topic of long-term study and targeting cell death is one of the most effective ways to repress tumor growth. Many studies have successfully demonstrated that metabolism is inextricably linked to cell death of cancer cells. Here we summarize the recently identified metabolic characters that specifically impact on different types of cell deaths and discuss their roles in tumorigenesis."

基金机构：National Natural Science Foundation of China

基金资助正文：Figures 1-5 were created with https://www.biorender.com/