"KHSO<sub>4</sub> promoted practical synthesis of quinazolin-4(<i>3H</i>)-ones and benzothiadiazine 1,1-dioxides"
作者全名："Zheng, Jiecheng; Gong, Feng; Wang, Wei; Wu, Yue; Zhao, Dezhang; Zhang, Tianyuan; Yang, Wenwen; Gan, Zongjie"
作者地址："[Zheng, Jiecheng; Gong, Feng; Wu, Yue; Zhao, Dezhang; Zhang, Tianyuan; Gan, Zongjie] Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing, Peoples R China; [Wang, Wei] Chongqing Fuling Inst Food & Drug Control, Chongqing, Peoples R China; [Yang, Wenwen] Chongqing Univ Ctr Hosp, Chongqing Peoples Hosp 4, Dept Ophthalmol, Chongqing, Peoples R China"
通信作者："Gan, ZJ (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing, Peoples R China.; Yang, WW (通讯作者)，Chongqing Univ Ctr Hosp, Chongqing Peoples Hosp 4, Dept Ophthalmol, Chongqing, Peoples R China."
来源：SYNTHETIC COMMUNICATIONS
ESI学科分类：CHEMISTRY
WOS号：WOS:001197652500001
JCR分区：Q3
影响因子：2.1
年份：2024
卷号：54
期号：9
开始页：758
结束页：768
文献类型：Article
关键词："Quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides; KHSO4; synthesis"
摘要："A broad scope of quinazolin-4(3H)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO4 promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and N, N-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO4 also makes this protocol more attractive. [Graphical Abstract]"
基金机构：National Natural Science Foundation of China [21907013]; National Natural Science Foundation of China [cstc2024ycjh-bgzxm0130]; Chongqing Talents project [W0152]; CQMU Program for Youth Innovation in Future Medicine
基金资助正文："We appreciate the financial support from the National Natural Science Foundation of China (No. 21907013), Chongqing Talents project (No. cstc2024ycjh-bgzxm0130) and CQMU Program for Youth Innovation in Future Medicine (W0152)."
