Irisin alters <sc>d</sc>-galactose-induced apoptosis by increasing caveolin-1 expression in C2C12 myoblasts and skeletal muscle fibroblasts

作者全名："Wu, Yaoxuan; Wu, Yongxin; Yu, Jing; Zhang, Yingxiao; Dai, Xin; Chen, Jinliang; Sun, Yue; Yang, Yongxue; Zhao, Kexiang; Xiao, Qian"

作者地址："[Wu, Yaoxuan; Yang, Yongxue] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Clin Med Coll 2, Geriatr Dis Inst Chengdu,Dept Geriatr,Affiliated P, Chengdu 611137, Peoples R China; [Wu, Yaoxuan; Wu, Yongxin; Yu, Jing; Zhang, Yingxiao; Chen, Jinliang; Sun, Yue; Zhao, Kexiang; Xiao, Qian] Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, 1St You Yi Rd, Chongqing 400010, Peoples R China; [Dai, Xin] Chongqing Med Univ, Yongchuan Hosp, Dept Gen Practice, Chongqing 400010, Peoples R China; [Chen, Jinliang] Zhejiang Univ, Affiliated Hosp 2, Dept Endocrinol, Sch Med, Hangzhou 310001, Peoples R China"

通信作者："Yang, YX (通讯作者)，Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Clin Med Coll 2, Geriatr Dis Inst Chengdu,Dept Geriatr,Affiliated P, Chengdu 611137, Peoples R China.; Zhao, KX (通讯作者)，Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, 1St You Yi Rd, Chongqing 400010, Peoples R China."

来源：MOLECULAR AND CELLULAR BIOCHEMISTRY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001197887000002

JCR分区：Q3

影响因子：4.3

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Irisin; Apoptosis; Fibroblast; Sarcopenia

摘要："Muscle atrophy and skeletal muscle fibrosis are significant pathological manifestations of primary sarcopenia. The regulation of C2C12 myoblast and skeletal muscle fibroblast apoptosis is associated with these pathological changes. Previous studies have indicated that irisin, the cleaved form of fibronectin type III domain-containing protein 5 (FNDC5), can alleviate primary sarcopenia. However, the mechanisms of the effect of irisin in age-related apoptosis remain unknown. Our present research aimed to explore the effect of irisin and the underlying mechanism of d-galactose (d-gal)-induced apoptosis in skeletal muscle fibroblasts and C2C12 myoblasts. We found the opposite effects of d-gal on C2C12 myoblasts and fibroblasts. We also found that irisin suppressed C2C12 cell apoptosis and promoted fibroblast apoptosis. Mechanistically, irisin altered d-gal-induced apoptosis by increasing caveolin-1 expression. Taken together, these findings further demonstrated that irisin is a potential agent that can treat aged-relative muscle atrophy and fibrosis."

基金机构："Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission"

基金资助正文：No Statement Available