p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2

作者全名："Liu, Jiao; Gao, Leiqiong; Zhou, Na; Jiang, Zhenghong; Che, Siyi; Deng, Yu; Zang, Na; Ren, Luo; Xie, Xiaohong; Xie, Jun; Liu, Enmei"

作者地址："[Liu, Jiao; Gao, Leiqiong; Zhou, Na; Jiang, Zhenghong; Che, Siyi; Deng, Yu; Zang, Na; Ren, Luo; Xie, Xiaohong; Xie, Jun; Liu, Enmei] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Resp Med,Minist Educ,Key Lab Child Dev & Diso, Chongqing 400014, Peoples R China; [Liu, Jiao; Gao, Leiqiong; Zhou, Na; Jiang, Zhenghong; Che, Siyi; Ren, Luo] Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Chongqing 400014, Peoples R China"

通信作者："Xie, J; Liu, EM (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Resp Med,Minist Educ,Key Lab Child Dev & Diso, Chongqing 400014, Peoples R China."

来源：VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001199030200001

JCR分区：Q2

影响因子：3.7

年份：2024

卷号：593

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Respiratory syncytial virus; p53; Toll -like receptor 2; Inflammation

摘要："-Respiratory syncytial virus (RSV) is a pivotal virus leading to acute lower respiratory tract infections in children under 5 years old. This study aimed to explore the correlation between p53 and Toll-like receptors (TLRs) post RSV infection. p53 levels exhibited a substantial decrease in nasopharyngeal aspirates (NPAs) from infants with RSV infection compared to control group. Manipulating p53 expression had no significant impact on RSV replication or interferon signaling pathway. Suppression of p53 expression led to heightened inflammation following RSV infection in A549 cells or airways of BALB/c mice. while stabilizing p53 expression using Nutlin3a mitigated the inflammatory response in A549 cells. Additionally, Inhibiting p53 expression significantly increased Toll-like receptor 2 (TLR2) expression in RSV-infected epithelial cells and BALB/c mice. Furthermore, the TLR2 inhibitor, C29, effectively reduced inflammation mediated by p53 in A549 cells. Collectively, our results indicate that p53 modulates the inflammatory response after RSV infection through TLR2."

基金机构：Key Project of Chongqing Natural Science Foundation [cstc2019jcyjzdxmX0030]; National Natural Science Foundation of China [81800009]; Millions Talent Projects of Chongqing (Chongqing Commission) [187]

基金资助正文："This research was supported by grants from the Key Project of Chongqing Natural Science Foundation (cstc2019jcyjzdxmX0030) , the National Natural Science Foundation of China (81800009) , and the Millions Talent Projects of Chongqing (Chongqing Commission [2018] , no. 187) ."