Maternal vitamin D status and risk of gestational diabetes mellitus in twin pregnancies: a longitudinal twin pregnancies birth cohort study

作者全名："Li, Da-yan; Wang, Lan; Li, Li; Zhou, Shuwei; Tan, Jiangyun; Tang, Chunyan; Liao, Qianqian; Liu, Ting; Wen, Li; Qi, Hong-bo"

作者地址："[Li, Da-yan] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Chongqing 400016, Peoples R China; [Li, Da-yan] Chongqing Med Univ, Banan Hosp, Dept Obstet & Gynecol, Chongqing 401320, Peoples R China; [Li, Da-yan; Wang, Lan; Li, Li; Zhou, Shuwei; Tan, Jiangyun; Tang, Chunyan; Liao, Qianqian; Liu, Ting; Wen, Li; Qi, Hong-bo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Longshan Rd 120, Chongqing 401147, Peoples R China; [Wang, Lan; Li, Li; Zhou, Shuwei; Tan, Jiangyun; Tang, Chunyan; Liao, Qianqian; Liu, Ting; Wen, Li; Qi, Hong-bo] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China"

通信作者："Wen, L; Qi, HB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Longshan Rd 120, Chongqing 401147, Peoples R China.; Wen, L; Qi, HB (通讯作者)，Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China."

来源：NUTRITION JOURNAL

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001199519300001

JCR分区：Q2

影响因子：5.4

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Vitamin D; Gestational diabetes mellitus; Twin pregnancies; China

摘要："Background Gestational diabetes mellitus (GDM) is a common complication of pregnancy, with significant short-term and long-term implications for both mothers and their offspring. Previous studies have indicated the potential benefits of vitamin D in reducing the risk of GDM, yet little is known about this association in twin pregnancies. This study aimed to investigate maternal vitamin D status in the second trimester and examine its association with the risk of GDM in twin pregnancies. Methods We conducted a prospective cohort study based on data from the Chongqing Longitudinal Twin Study (LoTiS). Peripheral blood serum was collected from the mothers in the second trimester to measure 25(OH)D concentrations. GDM was diagnosed at 23-26 weeks of gestation using a 75-g 2-h oral glucose tolerance test. We used multivariable logistic regression analyses to examine the correlations between vitamin D status and the risk of GDM. Results Of the total participants, 93 (29.9%) women were diagnosed with GDM. The mean serum 25(OH)D concentration in the second trimester was 31.1 +/- 11.2 ng/mL, and the rate of vitamin D insufficiency and deficiency were 23.5% and 18.7%, respectively. Compared to women with a 25(OH)D concentration < 30 ng/mL, those with a 25(OH)D concentration >= 30 ng/mL had a significantly lower risk of GDM (RR 0.61; 95% CI: 0.43, 0.86), especially those who were overweight before pregnancy (RR 0.32; 95% CI: 0.16, 0.64). The restricted cubic splines model showed an inverted J-shaped relationship between vitamin D concentrations and GDM risk. Conclusions The risk of GDM was significantly reduced in twin pregnant women with vitamin D concentrations >= 30 ng/mL in the second trimester."

基金机构：Chongqing Science and Technology Foundation

基金资助正文："The authors would like to thank all the families, health professionals and researchers who contributed to this cohort study."