Exposure to Endocrine-Disrupting Chemicals and Congenital Heart Diseases: The Pooled Results Based on the Current Evidence

作者全名："Dai, Jiangtao; Wang, Gang; Wu, Chun; Pan, Zhengxia; Li, Hongbo; Shen, Lianju; Wu, Yuhao"

作者地址："[Dai, Jiangtao; Wang, Gang; Wu, Chun; Pan, Zhengxia; Li, Hongbo; Wu, Yuhao] Chongqing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, Chongqing, Peoples R China; [Dai, Jiangtao; Wang, Gang; Wu, Chun; Pan, Zhengxia; Li, Hongbo; Shen, Lianju; Wu, Yuhao] Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Base Child Dev &, Minist Educ, Chongqing Key Lab Pediat,Key Lab Child Dev & Disor, Chongqing, Peoples R China"

通信作者："Wu, YH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, Chongqing, Peoples R China.; Wu, YH (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Base Child Dev &, Minist Educ, Chongqing Key Lab Pediat,Key Lab Child Dev & Disor, Chongqing, Peoples R China."

来源：PEDIATRIC CARDIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001200339300001

JCR分区：Q2

影响因子：1.6

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Endocrine-disrupting chemicals; Congenital heart diseases; Maternal exposure

摘要："The relationships between maternal exposure to endocrine-disrupting chemicals (EDCs) and congenital heart diseases (CHD) are not elucidated yet. The exposure levels of EDCs are generally estimated based on self-reported questionnaires or occupational exposure evaluations in the literature. Therefore, a study based on epidemiological data from human biospecimens is required to provide stronger evidence between maternal exposure to EDC and CHD. Embase, Pubmed, Scopus, and the Cochrane Library databases were searched for related research which provided risk estimates regarding the relationships between maternal EDC exposure and CHD in human offspring. Baseline characteristics and outcomes of CHD were extracted from each included study. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to calculate the overall estimates of CHD. Subgroup and meta-regression analyses were performed to identify the sources of heterogeneity. Bootstrapping techniques were used in analyses where several studies originated from a similar population. A total of seventeen studies were involved in the meta-analyses. Maternal EDC exposure was significantly related to CHD in offspring (OR 2.15; 95%CI 1.64 to 2.83). EDC exposure was significantly associated with septal defects (OR 2.34; 95%CI 1.77 to 3.10), conotruncal defects (OR 2.54; 95%CI 1.89 to 3.43), right ventricular outflow tract obstruction (OR 2.65; 95%CI 1.73 to 4.07), left ventricular outflow tract obstruction (OR 3.58; 95%CI 2.67 to 4.79), anomalous pulmonary venous return (OR 2.31; 95%CI 1.34 to 4.00), and other heart defects (OR 2.49; 95%CI 1.75 to 3.54). In addition, maternal exposure to heavy metals, which included lead (OR 2.19; 95%CI 1.29 to 3.71), cadmium (OR 1.81; 95%CI 1.28 to 2.56), mercury (OR 2.23; 95%CI 1.13 to 4.44), and manganese (OR 2.65; 95%CI 1.48 to 4.74), increased risks for CHD significantly. In conclusion, based on the latest evidence, maternal EDC exposure may increase CHD risks in human offspring, especially in heavy metal exposure conditions."

基金机构：Chongqing Medical University Program for Youth Innovation in Future Medicine

基金资助正文：None.