Dysregulations of amino acid metabolism and lipid metabolism in urine of children and adolescents with major depressive disorder: a case-control study

作者全名："Jiang, Yuanliang; Cai, Yuping; Teng, Teng; Wang, Xiaolin; Yin, Bangmin; Li, Xuemei; Yu, Ying; Liu, Xueer; Wang, Jie; Wu, Hongyan; He, Yuqian; Zhu, Zheng-Jiang; Zhou, Xinyu"

作者地址："[Jiang, Yuanliang; Teng, Teng; Yin, Bangmin; Li, Xuemei; Liu, Xueer; Wang, Jie; Wu, Hongyan; Zhou, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Cai, Yuping; Zhu, Zheng-Jiang] Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai, Peoples R China; [Wang, Xiaolin] Chongqing Med Univ, Affiliated Hosp 1, Hlth Management Ctr, Chongqing, Peoples R China; [Yu, Ying; He, Yuqian] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Zhu, Zheng-Jiang] Shanghai Key Lab Aging Studies, Shanghai, Peoples R China"

通信作者："Zhou, XY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China.; Zhu, ZJ (通讯作者)，Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai, Peoples R China.; Zhu, ZJ (通讯作者)，Shanghai Key Lab Aging Studies, Shanghai, Peoples R China."

来源：PSYCHOPHARMACOLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001200370000001

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Major depressive disorder; Children and adolescents; Urine; Metabolomics; Biomarker

摘要："RationaleThe mechanisms underlying major depressive disorder (MDD) in children and adolescents are unclear. Metabolomics has been utilized to capture metabolic signatures of various psychiatric disorders; however, urinary metabolic profile of MDD in children and adolescents has not been studied.ObjectivesWe analyzed urinary metabolites in children and adolescents with MDD to identify potential biomarkers and metabolic signatures.MethodsHere, liquid chromatography-mass spectrometry was used to profile metabolites in urine samples from 192 subjects, comprising 80 individuals with antidepressant-naive MDD (AN-MDD), 37 with antidepressant-treated MDD (AT-MDD) and 75 healthy controls (HC). We performed orthogonal partial least squares discriminant analysis to identify differential metabolites and employed logistic regression and receiver operating characteristic analysis to establish a diagnostic panel.ResultsIn total, 143 and 71 differential metabolites were identified in AN-MDD and AT-MDD, respectively. These were primarily linked to lipid metabolism, molecular transport, and small molecule biochemistry. AN-MDD additionally exhibited dysregulated amino acid metabolism. Compared to HC, a diagnostic panel of seven metabolites displayed area under the receiver operating characteristic curves of 0.792 for AN-MDD, 0.828 for AT-MDD, and 0.799 for all MDD. Furthermore, the urinary metabolic profiles of children and adolescents with MDD significantly differed from those of adult MDD.ConclusionsOur research suggests dysregulated amino acid metabolism and lipid metabolism in the urine of children and adolescents with MDD, similar to results in plasma metabolomics studies. This contributes to the comprehension of mechanisms underlying children and adolescents with MDD."

基金机构：the Major Program of Brain Science and Brain-Like Intelligence Technology; First Affiliated Hospital of Chongqing Medical University

基金资助正文："We gratefully acknowledge the staff from the Department of Psychiatry and the Health Management Center, the First Affiliated Hospital of Chongqing Medical University (Chongqing, China), for their contributions to subject recruitment and sample collection."