"Molecular epidemiology and resistance mechanisms of tigecycline-non-susceptible <i>Acinetobacter baumannii</i> isolated from a tertiary care hospital in Chongqing, China"

作者全名："Liao, Jiajia; Huang, Jinzhu; Xia, Peiwen; Yang, Bingxue; Dang, Zijun; Luo, Shengli; Tang, Shiyu; Li, Yuqiong; Han, Qi; Xia, Yun"

作者地址："[Liao, Jiajia; Huang, Jinzhu; Xia, Peiwen; Yang, Bingxue; Dang, Zijun; Luo, Shengli; Tang, Shiyu; Li, Yuqiong; Han, Qi; Xia, Yun] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Xia, Y (通讯作者)，Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001202495100002

JCR分区：Q2

影响因子：4.5

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Tigecycline-non-susceptible; Acinetobacter baumannii; RND efflux pump; Multi-locus sequence typing

摘要："We studied 34 isolates of Tigecycline-Non-Susceptible A. baumannii (TNAB) obtained from clinical specimens at a large tertiary care hospital in Chongqing, China. These 34 strains belonged to 8 different clones including ST195 (35.3%) and ST208 (17.7%). EBURST analysis found that these 8 ST types belonged to the Clonal Complex 92. Tigecycline resistance-associated genes adeR, adeS, adeL, adeN, rrf, rpsJ, and trm were detected in most strains. The expression level of the resistance-nodulation-cell division (RND) efflux pumps in TNAB strains was higher than the reference strain ATCC19606. 58.8% of strains had a decrease in the tigecycline minimum inhibitory concentration (MIC) after the addition of carbonyl cyanide 3-chlorophenylhydrazone (CCCP). The TNAB strains in our hospital have a high degree of affinity and antibiotic resistance. Regular surveillance should be conducted to prevent outbreaks of TNAB epidemics."

基金机构：National Natural Science Foundation of China

基金资助正文：No Statement Available