Gut microbiota-bile acids-glucagon like peptide-1 axis contributes the resistance to high fat diet-induced obesity in mice

作者全名："Chen, Chunxiu; Liu, Lingli; Zhong, Ying; Wang, Miaoran; Ai, Yanbiao; Hou, Yi; Chen, Hong; Lin, Xiaojing; Zhang, Yunqi; Ding, Min; Luo, Ting; Li, Jibin; Li, Xinyu; Xiao, Xiaoqiu"

作者地址："[Chen, Chunxiu; Luo, Ting; Xiao, Xiaoqiu] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing, Peoples R China; [Chen, Chunxiu; Liu, Lingli; Zhong, Ying; Wang, Miaoran; Ai, Yanbiao; Hou, Yi; Lin, Xiaojing; Zhang, Yunqi; Li, Xinyu; Xiao, Xiaoqiu] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Translat Med Major Metab Dis, Chongqing, Peoples R China; [Chen, Chunxiu; Liu, Lingli; Zhong, Ying; Wang, Miaoran; Ai, Yanbiao; Li, Jibin] Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Chongqing, Peoples R China; [Chen, Hong; Ding, Min] Chongqing Med Univ, Sch Lab Med, Key Lab Lab Med Diag, Minist Educ, Chongqing, Peoples R China; [Hou, Yi] Chongqing Med Univ, Expt Teaching & Management Ctr, Chongqing, Peoples R China; [Li, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, Chongqing, Peoples R China; [Xiao, Xiaoqiu] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Li, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Li, Jibin] Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 1 Yixueyuanlu Rd, Chongqing 400016, Peoples R China"

通信作者："Xiao, XQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Li, XY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Li, JB (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 1 Yixueyuanlu Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001003864800001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：117

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：bile acids; gut microbiota; diet induced obesity; brown adipose tissue; tauro-conjugated bile acids; obesity resistant

摘要："In human and rodents, some individuals may remain lean even when they are challenged with high calorie intake. Here, we used C57BL/6J mice to establish animal models of high-fat diet (HFD) induced obesity sensitive (DIO) mice and obesity resistant (DIR) mice. In DIR mice, improved metabolic profile through brown adipose tissue (BAT) activation was observed, while plasma unconjugated bile acids (BAs) were decreased together with increased intestine tauro-conjugated BAs (e.g., T-beta-MCA). The composition of the gut flora also differs greatly between DIR and DOR. Using fecal microbiota transplants from DIR mice, HFD fed recipient mice exhibited a trend toward reduced adiposity and improved glucose tolerance, showing increased serum tauro-conjugated BAs levels. STC-1 cell experiments confirmed T-beta-MCA could activate FXR/TGR5 pathway and induce the production of GLP-1, inhibiting genes that regulate the ceramide synthesis. Our results indicated that the DIR mice exhibited higher energy expenditure by activating BAT thermogenesis, which may be related to altered gut microbiota-bile acids-glucagon like peptide-1 axis. (c) 2023 Elsevier Inc. All rights reserved."

基金机构："National Natural Science Foundation of China [82071734, 81871222]; Scientific and Health Joint Medical Research Project of Chongqing; [2021MSXM101]"

基金资助正文："This work was supported by the National Natural Science Foundation of China to XX (Grant NO.: 82071734 , 81871222) and Scientific and Health Joint Medical Research Project of Chongqing to XL (Grant NO: 2021MSXM101) ."