Pathogenesis and Management of Acute Necrotizing Encephalopathy

作者全名："Qin, Ningxiang; Wang, Jing; Peng, Xi; Wang, Liang"

作者地址："[Qin, Ningxiang; Wang, Jing; Wang, Liang] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Peng, Xi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Wang, L (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Peng, X (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：EXPERT REVIEW OF NEUROTHERAPEUTICS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001004251400001

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：23

期号：7

开始页：641

结束页：650

文献类型：Review

关键词：acute necrotizing encephalopathy; accessory infection; COVID-19; influenza; cytokine storm

摘要："IntroductionDuring the COVID-19 pandemic, many cases of acute necrotizing encephalopathy (ANE) secondary to COVID-19 have been reported. ANE is characterized by a rapid onset, a fulminant course, and low morbidity and fatality rates. Therefore, clinicians need to be vigilant for such disorders, especially during the influenza virus and COVID-19 epidemics.Areas coveredThe authors summarize the most recent studies on the clinical spectrum and treatment essentials of ANE to provide references for prompt diagnosis and improved treatment of this rare but fatal disease.Expert opinionANE is a type of necrotizing lesion of the brain parenchyma. There are two major types of reported cases. One is isolated and sporadic ANE, which is primarily caused by viral infections, particularly influenza and HHV-6 virus. The other type is familial recurrent ANE, which is caused by RANBP2 gene mutations. ANE patients have rapid progression and a very poor prognosis, with acute brain dysfunction occurring within days of viral infection and requiring admission to the intensive care unit. Clinicians still need to investigate and find solutions for the problems of early detection and treatment of ANE."

基金机构："Joint Medical Research Project of Chongqing Science & Technology and Health Commission [2020FYYX081]; High-Level Medical Reserved Personnel Training Project of Chongqing; Natural Science Foundation of Yuzhong Direct, Chongqing [20190129]"

基金资助正文："This work was supported by the Joint Medical Research Project of Chongqing Science & Technology and Health Commission (2020FYYX081) the High-Level Medical Reserved Personnel Training Project of Chongqing, and the Natural Science Foundation of Yuzhong Direct, Chongqing (20190129)."