The brain activity pattern in alcohol-use disorders under inhibition response Task

作者全名："Cao, Yuan; Tian, Fangfang; Zeng, Jianguang; Gong, Qiyong; Yang, Xun; Jia, Zhiyun"

作者地址："[Cao, Yuan; Jia, Zhiyun] Sichuan Univ, Dept Nucl Med, West China Hosp, Chengdu 610041, Peoples R China; [Gong, Qiyong] West China Hosp Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu 610041, Peoples R China; [Tian, Fangfang] Chongqing Med Univ, Dept Nucl Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Zeng, Jianguang] Chongqing Univ, Sch Econ & Business Adm, Chongqing 400044, Peoples R China; [Gong, Qiyong; Jia, Zhiyun] Chinese Acad Med Sci, Sichuan Univ, Psychoradiol Res Unit, West China Hosp,2018RU011, Chengdu, Sichuan, Peoples R China; [Yang, Xun] Chongqing Univ, Sch Publ Affairs, Chongqing 400044, Peoples R China; [Jia, Zhiyun] Sichuan Univ, West China Hosp, Dept Nucl Med, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China; [Yang, Xun] Chongqing Univ, Sch Publ Affairs, Chongqing, Peoples R China"

通信作者："Jia, ZY (通讯作者)，Sichuan Univ, West China Hosp, Dept Nucl Med, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China.; Yang, X (通讯作者)，Chongqing Univ, Sch Publ Affairs, Chongqing, Peoples R China."

来源：JOURNAL OF PSYCHIATRIC RESEARCH

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001007169400001

JCR分区：Q1

影响因子：3.7

年份：2023

卷号：163

期号：　

开始页：127

结束页：134

文献类型：Article

关键词：Alcohol use disorder; Brain Image; Inhibition response

摘要："Background: Inhibitory control impairment in alcohol use disorder (AUD) may indicate detrimental effects of chronic alcohol use on different functional systems in the brain, but the current studies lack consistency. This study aims to identify the most consistent response inhibition-related brain dysfunction based on existing data.Methods: We performed systematic searches of the PubMed, Embase, Web of Science, and PsychINFO databases for available studies. Anisotropic effect-size signed differential mapping was used to quantitatively analyze the differences in response inhibition-related brain activation between AUD patients and HCs. Meta regression was used to explore the relationship between brain alterations and clinical variables.Results: The brain hypoactivation or hyperactivation in AUD patients compared with HCs during the response inhibition tasks was mainly located in the prefrontal cortex including the superior frontal gyrus, inferior frontal gyrus, and middle frontal gyrus, anterior cingulate gyrus (ACC), superior temporal gyrus, occipital gyrus, and somatosensory areas including postcentral gyrus and supramarginal gyrus. The meta-regression revealed that older patients were more likely to present activation in the left superior frontal gyrus when performing the response inhibition tasks.Conclusions: The response inhibitive dysfunctions in a distinct prefrontal-cingulate cortices may presumably reflect the core impairment in cognitive control abilities. Dysfunction in the occipital gyrus and somatosensory areas may indicate an abnormal motor-sensory and visual function in AUD. Such functional abnormalities may represent neurophysiological correlates of the executive deficits observed in AUD patients. This study has been registered in PROSPERO (number CRD42022339384)."

基金机构："National Natural Science Founda- tion of China [82271947, 81971595, 31700964]; Key Program of the National Natural Science Foundation of Sichuan Prov- ince [2022NSFSC0047]; Fundamental Research Funds for the Central Universities of China [2020CDJSK01XK02]; Social Science Foundation of Chongqing [2020YBGL80]"

基金资助正文："This study was supported by the National Natural Science Founda- tion of China (Grant Nos. 82271947, 81971595 and 31700964) , the Key Program of the National Natural Science Foundation of Sichuan Prov- ince (Grant No. 2022NSFSC0047) , the Fundamental Research Funds for the Central Universities of China (Grant No. 2020CDJSK01XK02) , and the Social Science Foundation of Chongqing (Grant No. 2020YBGL80) ."