Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges

作者全名："Lei, Xiaotian; Qiu, Sheng; Yang, Gangyi; Wu, Qinan"

作者地址："[Lei, Xiaotian; Qiu, Sheng; Yang, Gangyi] Chongqing Med Univ, Affiliated Hosp 2, Endocrinol Dept, Chongqing 400000, Peoples R China; [Lei, Xiaotian] Army Med Univ, Affiliated Hosp 1, Endocrinol Dept, Chongqing 400038, Peoples R China; [Wu, Qinan] Chongqing Med Univ, Peoples Hosp Dazu, Dazu Hosp, Endocrinol Dept, Chongqing 402360, Peoples R China"

通信作者："Yang, GY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Endocrinol Dept, Chongqing 400000, Peoples R China.; Wu, QA (通讯作者)，Chongqing Med Univ, Peoples Hosp Dazu, Dazu Hosp, Endocrinol Dept, Chongqing 402360, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001017193000001

JCR分区：Q1

影响因子：6.9

年份：2023

卷号：10

期号：4

开始页：1525

结束页：1536

文献类型：Review

关键词：Adipokine; Adiponectin; Inflammation; Metabolic cardiovascular disease; Obesity

摘要："Metabolic cardiovascular diseases have become a global health concern, and some of their risk factors are linked to several metabolic disorders. They are the leading causes of death in developing countries. Adipose tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological processes. Adiponectin is the most abundant pleiotropic adipokine and can increase insulin sensitivity, improve atherosclerosis, have anti-inflammatory properties, and exert a cardioprotective effect. Low adiponectin con-centrations are correlated with myocardial infarction, coronary atherosclerotic heart disease, hypertrophy, hypertension, and other metabolic cardiovascular dysfunctions. However, the relationship between adiponectin and cardiovascular diseases is complex, and the specific mechanism of action is not fully understood. Our summary and analysis of these issues are ex-pected to contribute to future treatment options.& COPY; 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/)."

基金机构："National Natural Science Foundation of China [82000792]; General Project of Chongqing Natural Science Foundation (China) [cstc2020jcyj-msxm0409]; Chongqing Science and Technology Bureau and Health Commission of Chinese Medicine Technology Innovation and Application Develop- ment Project (China) [2020ZY013540]; General Project of Graduate Education and Teaching Reform of Chongqing University, Chongqing, China [cquyjg20329]; Science and Health Joint Project of Dazu District Science and Technology Bureau (China) [2022CCC1001]"

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (No. 82000792) ; General Project of Chongqing Natural Science Foundation (China) (No. cstc2020jcyj-msxm0409) ; Chongqing Science and Technology Bureau and Health Commission of Chinese Medicine Technology Innovation and Application Develop- ment Project (China) (No. 2020ZY013540) ; General Project of Graduate Education and Teaching Reform of Chongqing University, Chongqing, China (No. cquyjg20329) ; and Science and Health Joint Project of Dazu District Science and Technology Bureau (China) (No. DZKJ, 2022CCC1001) ."