Pyroptosis: A road to next-generation cancer immunotherapy

作者全名："Fang, Yiliang; Tang, Yaxing; Huang, Bo"

作者地址："[Huang, Bo] Chinese Acad Med Sci CAMS & Peking Union Med Coll, Inst Basic Med Sci, Dept Immunol, Beijing 100005, Peoples R China; [Huang, Bo] Chinese Acad Med Sci CAMS & Peking Union Med Coll, Inst Basic Med Sci, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China; [Fang, Yiliang] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China; [Fang, Yiliang] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Southwest Canc Ctr, Chongqing 400038, Peoples R China; [Tang, Yaxing] Chongqing Med Univ, Affiliated Hosp 2, Dept Anaesthesiol, Chongqing 400010, Peoples R China"

通信作者："Huang, B (通讯作者)，Chinese Acad Med Sci CAMS & Peking Union Med Coll, Inst Basic Med Sci, Dept Immunol, Beijing 100005, Peoples R China.; Huang, B (通讯作者)，Chinese Acad Med Sci CAMS & Peking Union Med Coll, Inst Basic Med Sci, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China."

来源：SEMINARS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001018300500001

JCR分区：Q1

影响因子：7.4

年份：2023

卷号：68

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Pyroptosis; Cancer immunotherapy; Gasdermin; Tumor microenvironment

摘要："The goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8(+)T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to robust antitumor immunity. Exploring nanoparticles and other approaches to spatiotemporally control tumor pyroptosis by regulating gasdermin expression and activation is promising for next-generation immunotherapy."

基金机构："National Natural Science Foundation of China [81788101, 32100707]; CAMS Innovation Fund for Medical Sci- ences (CIFMS) [2021-I2M-1-021]; Haihe Laboratory of Cell Ecosystem Innovation Fund [HH22KYZX0009]; Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0197]"

基金资助正文："This work was supported by National Natural Science Foundation of China (81788101, 32100707) , CAMS Innovation Fund for Medical Sci- ences (CIFMS) (2021-I2M-1-021) , Haihe Laboratory of Cell Ecosystem Innovation Fund (HH22KYZX0009) , and Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX0197) ."