Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity

作者全名："Wang, Hao-Tian; Zhao, Long; Yang, Li-Qin; Ge, Ming-Xia; Yang, Xing-Li; Gao, Zong-Liang; Cun, Yu-Peng; Xiao, Fu-Hui; Kong, Qing-Peng"

作者地址："[Wang, Hao-Tian; Zhao, Long; Yang, Li-Qin; Ge, Ming-Xia; Yang, Xing-Li; Gao, Zong-Liang; Xiao, Fu-Hui; Kong, Qing-Peng] Chinese Acad Sci, Kunming Inst Zool, KIZ CUHK Joint Lab Bioresources & Mol Res Common D, Key Lab Hlth Aging Res Yunnan Prov,Kunming Key Lab, Kunming, Peoples R China; [Zhao, Long; Ge, Ming-Xia; Yang, Xing-Li; Gao, Zong-Liang] Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Peoples R China; [Cun, Yu-Peng] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Pediat R, Chongqing 400014, Peoples R China; [Kong, Qing-Peng] Chinese Acad Sci, CAS Ctr Excellence Anim Evolut & Genet, Kunming, Peoples R China; [Xiao, Fu-Hui; Kong, Qing-Peng] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650201, Peoples R China"

通信作者："Cun, YP (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Pediat R, Chongqing 400014, Peoples R China.; Xiao, FH; Kong, QP (通讯作者)，Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650201, Peoples R China."

来源：AGING CELL

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001018709300001

JCR分区：Q1

影响因子：8

年份：2023

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文献类型：Article; Early Access

关键词：centenarian; healthy aging; longevity; somatic mutation

摘要："Somatic mutations accumulate with age and are associated closely with human health, their characterization in longevity cohorts remains largely unknown. Here, by analyzing whole genome somatic mutation profiles in 73 centenarians and 51 younger controls in China, we found that centenarian genomes are characterized by a markedly skewed distribution of somatic mutations, with many genomic regions being specifically conserved but displaying a high function potential. This, together with the observed more efficient DNA repair ability in the long-lived individuals, supports the existence of key genomic regions for human survival during aging, with their integrity being of essential to human longevity."

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