Multi-characteristic reinforcement of horizontally integrated TENet based on wrist bone development criteria for pediatric bone age assessment

作者全名："Jian, Kunyuan; Li, Shuxiang; Yang, Mengning; Wang, Simin; Song, Cui"

作者地址："[Jian, Kunyuan; Yang, Mengning; Wang, Simin] Chongqing Univ, Sch Big Data & Software Engn, Chongqing 401331, Peoples R China; [Li, Shuxiang; Song, Cui] Chongqing Med Univ, Dept Endocrinol & Genet Metab Dis, Childrens Hosp, Chongqing 400016, Peoples R China"

通信作者："Yang, MN (通讯作者)，Chongqing Univ, Sch Big Data & Software Engn, Chongqing 401331, Peoples R China."

来源：APPLIED INTELLIGENCE

ESI学科分类：ENGINEERING

WOS号：WOS:001020246700001

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Deep learning; Bone age assessment; CHN-05; Multi-feature reinforcement

摘要："Pediatric bone age assessment (BAA) is an essential human physiological examination that reflects human growth potential and sexual maturation trends. In clinical practice, the ""Methodology for Bone Maturation and Evaluation of the Wrist in Chinese Adolescent Children"" (CHN-05) is a widely used method for BAA by Chinese radiologists. CHN-05 adopts the metacarpal length (ML) as well as the metacarpal margin (MM) as reference standards to estimate bone age. Inspired by the semantic description of CHN-05, we propose a new model, called a topology and edge map composed of a network(TENet), for automatic bone age assessment. In TENet, we design a hand topology module to recognize key hand locations and extract structural semantics. In addition, we devise an edge feature enhancement module to supply precise skeletal edge information throughout the training process. Our model can detect the overall message of edges alongside the local message of topology for the purpose of multi-feature horizontally fused assessment of bone age. Experimental results show that our TENet achieves a state-of-the-art model performance of 5.35 mean absolute error (MAE) on the public dataset RSNA. Since our model for designing follows CHN-05 semantic logic, it is reliable and interpretable in terms of clinical use."

基金机构：Fundamental Research Project of the National Clinical Medical Research Center for Child Health and Disease [NCRCCHD-2020-GP-10]; Future Medicine Youth Innovation Team Development Support Project of Chongqing Medical University [W0110]

基金资助正文：This work was supported by the Fundamental Research Project of the National Clinical Medical Research Center for Child Health and Disease [grant numbers NCRCCHD-2020-GP-10]; and the Future Medicine Youth Innovation Team Development Support Project of Chongqing Medical University [grant numbers W0110].