Daytime-restricted feeding enhances running endurance without prior exercise in mice

作者全名："Xin, Haoran; Huang, Rongfeng; Zhou, Meiyu; Chen, Jianghui; Zhang, Jianxin; Zhou, Tingting; Ji, Shushen; Liu, Xiao; Tian, He; Lam, Sin Man; Bao, Xinyu; Li, Lihua; Tong, Shifei; Deng, Fang; Shui, Guanghou; Zhang, Zhihui; Wong, Catherine C. L.; Li, Min-Dian"

作者地址："[Xin, Haoran; Huang, Rongfeng; Zhou, Meiyu; Chen, Jianghui; Zhang, Jianxin; Bao, Xinyu; Li, Lihua; Zhang, Zhihui; Li, Min-Dian] Army Med Univ, Southwest Hosp, Ctr Circadian Metab & Cardiovasc Dis, Dept Cardiovasc Med, Chongqing, Peoples R China; [Chen, Jianghui; Tong, Shifei] Chongqing Med Univ, Affiliated Hosp 3, Dept Cardiol, Chongqing, Peoples R China; [Zhou, Tingting; Wong, Catherine C. L.] Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China; [Ji, Shushen; Liu, Xiao] GFK Biotech, Dept Bioinformat, Shanghai, Peoples R China; [Tian, He; Lam, Sin Man; Shui, Guanghou] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China; [Lam, Sin Man] LipidALL Technol, Changzhou, Peoples R China; [Deng, Fang] Army Med Univ, Coll High Altitude Mil Med, Dept Pathophysiol, Chongqing, Peoples R China; [Wong, Catherine C. L.] Tsinghua Univ, Peking Univ Joint Ctr Life Sci, Beijing, Peoples R China"

通信作者："Zhang, ZH; Li, MD (通讯作者)，Army Med Univ, Southwest Hosp, Ctr Circadian Metab & Cardiovasc Dis, Dept Cardiovasc Med, Chongqing, Peoples R China.; Wong, CCL (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China.; Wong, CCL (通讯作者)，Tsinghua Univ, Peking Univ Joint Ctr Life Sci, Beijing, Peoples R China."

来源：NATURE METABOLISM

ESI学科分类：　

WOS号：WOS:001021119800002

JCR分区：Q1

影响因子：18.9

年份：2023

卷号：5

期号：7

开始页：1236

结束页：+

文献类型：Article

关键词：　

摘要："Physical endurance and energy conservation are essential for survival in the wild. However, it remains unknown whether and how meal timing regulates physical endurance and muscle diurnal rhythms. Here, we show that day/sleep time-restricted feeding (DRF) enhances running endurance by 100% throughout the circadian cycle in both male and female mice, compared to either ad libitum feeding or night/wake time-restricted feeding. Ablation of the circadian clock in the whole body or the muscle abolished the exercise regulatory effect of DRF. Multi-omics analysis revealed that DRF robustly entrains diurnal rhythms of a mitochondrial oxidative metabolism-centric network, compared to night/wake time-restricted feeding. Remarkably, muscle-specific knockdown of the myocyte lipid droplet protein perilipin-5 completely mimics DRF in enhancing endurance, enhancing oxidative bioenergetics and outputting rhythmicity to circulating energy substrates, including acylcarnitine. Together, our work identifies a potent dietary regimen to enhance running endurance without prior exercise, as well as providing a multi-omics atlas of muscle circadian biology regulated by meal timing. Time-restricted feeding in the resting period is a potent dietary regimen to enhance running endurance in mice, by synchronizing rhythms of perilipin-5 in muscle tissues through involvement of the circadian clock."

基金机构："National Natural Science Foundation of China [32271208, 92057109, 81900776, 32150005]; Chongqing Science Fund for Distinguished Young Scholars [CSTB2022NSCQ-JQX0009]; National Key Research and Development Programme of China [2022YFA0806001]; CAMS Innovation Fund for Medical Sciences [2022-I2M-1-004]"

基金资助正文："AcknowledgementsPer1/Per2-DKO mice were gifted from E. E. Zhang, and bred by J. R. He. Bmal1fl/fl mice were gifted from W. He. We thank D. Zhu, Z. Gan, Z. Meng and L. Xie for suggestions. This study was supported by National Natural Science Foundation of China Grants (32271208 to M.-D.L., 92057109 to M.-D.L., 81900776 to M.-D.L. and 32150005 to C.C.L.W.), Chongqing Science Fund for Distinguished Young Scholars (CSTB2022NSCQ-JQX0009 to M.-D.L.), National Key Research and Development Programme of China (2022YFA0806001 to C.C.L.W.), CAMS Innovation Fund for Medical Sciences (2022-I2M-1-004 to C.C.L.W.)."