Phosphorylcholine/Heparin Composite Coatings on Artificial Lung Membrane for Enhanced Hemo-compatibility

作者全名："Sheng, Donghai; Zhang, Lin; Jia, Hao; Guo, Baoming; Zhang, Xiangjun; Li, Yuan"

作者地址："[Sheng, Donghai; Zhang, Lin; Jia, Hao; Guo, Baoming; Zhang, Xiangjun] Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol, Beijing 100084, Peoples R China; [Li, Yuan] Chongqing Med Univ, Cent Lab, Yongchuan Hosp, Chongqing 402160, Peoples R China"

通信作者："Zhang, L (通讯作者)，Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol, Beijing 100084, Peoples R China.; Li, Y (通讯作者)，Chongqing Med Univ, Cent Lab, Yongchuan Hosp, Chongqing 402160, Peoples R China."

来源：LANGMUIR

ESI学科分类：CHEMISTRY

WOS号：WOS:001023136500001

JCR分区：Q2

影响因子：3.7

年份：2023

卷号：39

期号：28

开始页：9796

结束页：9807

文献类型：Article

关键词：　

摘要："As the key component of extracorporeal membrane oxygenation (ECMO), artificial lung membranes have low gas permeability and plasma leakage problems, and the contact between membrane materials and blood can cause coagulation, leading to the blockage of medical equipment and seriously threatening the safety of human life. In our work, poly(4-methyl-1-pentene) hollow fiber membranes (PMP HFMs) were prepared by the thermally induced phase separation (TIPS) method, the redox method was adopted for the surface hydroxylation of PMP HFMs, and then, heparin (Hep) and 2-(methacryloyloxy)ethyl(2-(trimethylammonio)ethyl) phosphate (MPC) were grafted to the surface of PMP HFMs to prepare anticoagulant coatings. The gas permeability and hemo-compatibility of the coatings were investigated by various characterization methods, such as gas flow meter, scanning electron microscope, extracorporeal circulation experiment, etc. The results show that PMP HFMs possess a bicontinuous pore structure with a dense surface layer, which could maintain good gas permeability with an oxygen permeance of 0.8 mL/bar center dot cm(2)center dot min and stable gas selectivity. Furthermore, the whole blood circulation of rabbit indicated that a composite surface of bioactive Hep and biopassive MPC might be used as artificial lung membranes without the formation of thrombosis within 21 days."

基金机构："Tribology Science Fund of State Key Laboratory of Tribology, Tsinghua University [61012205321]"

基金资助正文："We acknowledge the support of this work by the Tribology Science Fund of State Key Laboratory of Tribology, Tsinghua University (Grants 61012205321)."