Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases

作者全名："Yuan, Xiaofan; Shen, Guanru; Xiao, Hongmei; Wang, Zijie; Ma, Yue; Qin, Xinyue"

作者地址："[Yuan, Xiaofan; Shen, Guanru; Xiao, Hongmei; Wang, Zijie; Ma, Yue; Qin, Xinyue] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Yixueyuan Rd, Chongqing, Peoples R China"

通信作者："Qin, XY (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Yixueyuan Rd, Chongqing, Peoples R China."

来源：CARDIOVASCULAR DRUGS AND THERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001024557800001

JCR分区：Q2

影响因子：3.1

年份：2023

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期号：　

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文献类型：Review; Early Access

关键词：Atherosclerosis; NGPs; Netrin-1; RGMa

摘要："BackgroundsNeuronal guidance proteins (NGPs) have been demonstrated to guide the elongation of neuronal axonal growth cones in the developing central nervous system. Non-neuronal functions of NGPs have also been described, especially in relation to atherosclerosis.FindingsNetrin-1 and repulsive guidance molecule a (RGMa) are NGPs that have been shown to regulate endothelial cell adhesion and angiogenesis, macrophage migration and apoptosis, smooth muscle cells (SMCs) phenotypic dedifferentiation and mobility, chemokine activities, and inflammatory responses during atherosclerosis initiation and progression.PurposesHowever, mechanistic studies have generated controversy about the specific role of Netrin-1 in atherosclerosis due to the diversity of its structure, receptors and cell sources, and the actions of RGMa in atherosclerosis have not been reported in previous reviews. Therefore, the current work reviews the evidence for roles of Netrin-1 and RGMa in the initiation and progression of atherosclerosis and discusses potential therapeutic targets in the future."

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