Chorionicity-associated variation in metabolic phenotype of cord blood in twin

作者全名："Liu, Xiaoyu; Yang, Jing; Ran, Rui; Long, Fei; Yang, Yang; Dong, Xiaojing; Saffery, Richard; Novakovic, Boris; Mousa, Hatem; Wei, Yuan; Hu, Lina; Han, Ting-Li"

作者地址："[Liu, Xiaoyu; Ran, Rui; Dong, Xiaojing; Hu, Lina; Han, Ting-Li] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Yang, Jing; Wei, Yuan] Peking Univ Third Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China; [Long, Fei] Chongqing Med Univ, Sch Biomed Engn, State Key Lab Ultrasound Engn Med Cofounded Chongq, Chongqing, Peoples R China; [Yang, Yang] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Saffery, Richard; Novakovic, Boris] Murdoch Childrens Res Inst, Mol Immun, Melbourne, Vic, Australia; [Saffery, Richard; Novakovic, Boris] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia; [Mousa, Hatem] Univ Leicester NHS Trust, Leicester, Leics, England; [Han, Ting-Li] Chongqing Med Univ, Life Sci Inst, Mass Spectrometry Ctr Maternal Fetal Med, Chongqing, Peoples R China"

通信作者："Hu, LA; Han, TL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Chongqing, Peoples R China.; Wei, Y (通讯作者)，Peking Univ Third Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China.; Han, TL (通讯作者)，Chongqing Med Univ, Life Sci Inst, Mass Spectrometry Ctr Maternal Fetal Med, Chongqing, Peoples R China."

来源：NUTRITION & METABOLISM

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001024883100001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：20

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Twin pregnancies; Umbilical cord plasma; Monochorionic; MC; Dichorionic; DC; Metabolomics

摘要："BackgroundMonochorionic (MC) twins present a higher incidence of unfavorable clinical perinatal outcomes than dichorionic (DC) twins, often in association with placental vascular anastomosis. In this study, we profiled the umbilical cord plasma metabolomes of uncomplicated MC and DC twin pregnancies and related these to several offspring outcomes, previously associated with birthweight.MethodsUmbilical vein blood samples were collected at birth from 25 pairs of uncomplicated MC twins and 24 pairs of uncomplicated DC twins. The samples were subjected to gas chromatography-mass spectrometry-based metabolomics. 152 metabolites were identified from the cord plasma samples of MC and DC twins. Partial least squares discriminant analysis and pathway analysis were performed to compare within DC/MC twin pairs and between DC and MC twins. A generalized estimating equation (GEE) model was utilized to explore the correlation between metabolic differences and birthweight discordance within and between twin pairs.ResultsOur study revealed clear differences between the metabolite profiles of umbilical cord plasma of MC and DC twins. Metabolite profiles in MC within twin pairs and DC within twin pairs were characterized by the differences in 2 - hydroxyglutaramic acid levels and nicotinamide levels, respectively. The metabolic pathways of GSH, tryptophan, and fatty acid metabolism, were significantly downregulated in MC twins compared to DC twins. In addition, the concentration of caffeine and decamethyl-cyclopentasiloxane (D5) was positively correlated with birthweight in MC and DC twins.ConclusionThis study demonstrated that the altered metabolites in umbilical plasma made contributions to the different chorionicities between uncomplicated MC twins and DC twins. The chorionicity of twins seems to affect the metabolic cross-talk between co-twin pairs and be related to birthweight discordance of twins."

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