A New Floating Piezoelectric Microphone for Fully Implantable Cochlear Implants in Middle Ear

作者全名："Xu, Xin-Da; Zhang, Wei-Xun; Jia, Xian-Hao; Wu, Yong-Zhen; Kang, Hou-Yong; Chi, Fang-Lu; Gao, Na"

作者地址："[Xu, Xin-Da; Zhang, Wei-Xun; Jia, Xian-Hao; Wu, Yong-Zhen; Chi, Fang-Lu; Gao, Na] Fudan Univ, Eye Ear Nose & Throat Hosp, Dept Otol & Skull Base Surg, 83 Fenyang Rd, Shanghai 200031, Peoples R China; [Xu, Xin-Da; Zhang, Wei-Xun; Jia, Xian-Hao; Wu, Yong-Zhen; Chi, Fang-Lu; Gao, Na] Shanghai Auditory Med Ctr, Shanghai, Peoples R China; [Xu, Xin-Da; Zhang, Wei-Xun; Jia, Xian-Hao; Wu, Yong-Zhen; Chi, Fang-Lu; Gao, Na] Fudan Univ, NHC Key Lab Hearing Med, Shanghai, Peoples R China; [Kang, Hou-Yong] Chongqing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Chongqing, Peoples R China"

通信作者："Chi, FL; Gao, N (通讯作者)，Fudan Univ, Eye Ear Nose & Throat Hosp, Dept Otol & Skull Base Surg, 83 Fenyang Rd, Shanghai 200031, Peoples R China."

来源：LARYNGOSCOPE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001025474700001

JCR分区：Q1

影响因子：2.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：piezoelectric microphone; totally implantable cochlear implant

摘要："Objective: Our team designed a long-lasting, well-sealed microphone, which uses laser welding and vacuum packaging technology. This study examined the sensitivity and effectiveness of this new floating piezoelectric microphone (NFPM) designed for totally implantable cochlear implants (TICIs) in animal experiments and intraoperative testing. Methods: Different NFPM frequency responses from 0.25 to 10 kHz at 90 dB SPL were analyzed using in vivo testing of cats and human patients. The NFPM was tested in different positions that were clamped to the ossicular chains or placed in the tympanic cavity of cats and human patients. Two volunteers' long incus foot and four cats' malleus neck of the ossicular chain were clamped with the NSFM. The output electrical signals from different locations were recorded, analyzed, and compared. The NFPM was removed after the test without causing any damage to the middle-ear structure of the cats. Intraoperative tests of the NFPM were performed during the cochlear implant surgery and the cochlear implant surgery was completed after all tests. Results: Compared with the results in the tympanic cavity, the NFPM could detect the vibration from the ossicular chain more sensitively in cat experiments and intraoperative testing. We also found that the signal output level of the NFPM decreased as the acoustic stimulation strength decreased in the intraoperative testing. Conclusion: The NFPM is effective in the intraoperative testing, making it feasible as an implantable middle-ear microphone for TICIs."

基金机构："National Natural Science Foundation of China [81700915, 81420108010, 81271084]; Shanghai 2020 Science and Technology Innovation Action Plan One Belt One Road International Cooperation Project [20410740600]; Clinical Research Plan of SHDC [SHDC2020CR1049B]; Innovation Project of the Shanghai Municipal Science and Technology Commission [22S31903100, 11411952300]"

基金资助正文："This study was supported by grants from the National Natural Science Foundation of China (81700915 to X.D., 81420108010, 81271084 to F.C.), the Shanghai 2020 Science and Technology Innovation Action Plan One Belt One Road International Cooperation Project(20410740600 to W.Z.), Clinical Research Plan of SHDC(SHDC2020CR1049B to W.Z.) and the Innovation Project of the Shanghai Municipal Science and Technology Commission (22S31903100, 11411952300 to F.C)."