Clinical features of severe Mycoplasma pneumoniae pneumonia with pulmonary complications in childhood: A retrospective study

作者全名："Luo, Xue qin; Luo, Jian; Wang, Chong jie; Luo, Zheng xiu; Tian, Dai yin; Xie, Xiao hong"

作者地址："[Luo, Xue qin; Luo, Jian; Wang, Chong jie; Luo, Zheng xiu; Tian, Dai yin; Xie, Xiao hong] Natl Clin Res Ctr Child Hlth & Disorders Chongqing, Chongqing Key Lab Pediat, China Int Sci & Technol Cooperat Base Child Dev &, Div Resp Med,Minist Educ,Key Lab Child Dev & Disor, Chongqing, Peoples R China; [Xie, Xiao hong] Chongqing Med Univ, Div Resp Med, Childrens Hosp, 136,Zhongshan 2nd Rd, Chongqing 400014, Peoples R China"

通信作者："Xie, XH (通讯作者)，Chongqing Med Univ, Div Resp Med, Childrens Hosp, 136,Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：PEDIATRIC PULMONOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001025929800001

JCR分区：Q1

影响因子：2.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：children; Mycoplasma pneumoniae pneumonia; pulmonary complications

摘要："IntroductionIncidence of severe M. pneumoniae pneumonia (SMPP) reported in China has been increasing over the last decade. We aimed to evaluate the clinical features of pediatric SMPP with pulmonary complications, according to laboratory tests and chest radiographic resolution patterns. Material and MethodsWe retrospectively reviewed 93 SMPP patients between January 2016 and February 2019, and grouped them by pneumonia pattern: pulmonary complications (63 patients) and extensive lung lesions without pulmonary complications (30 patients). ResultsSMPP patients with pleural effusion (medium or large) and necrotizing pneumonia showed longer duration of fever, high serum value of lactate dehydrogenase (LDH), d-dimer, and LDH to albumin ratio (LAR). LAR and d-dimer were associated with moderate or massive pleural effusion, and d-dimer was associated with lung necrosis. The average time of radiographic resolution in the pulmonary complication group was 12 weeks, while those with elevated d-dimer were significantly more likely to have longer time for radiographic clearance. ConclusionWe conclude that M. pneumoniae pneumonia in patients with pleural effusion (medium or large) or lung necrosis was more severe than those without pulmonary complications. LAR and d-dimer might be used as parameters to identify children susceptible to pleural effusion (medium or large) or lung necrosis, and longer time for radiographic clearance among pediatric patients of SMPP."

基金机构："Chongqing Science and Technology Committee [cstc2017shmsA130036]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0063]"

基金资助正文："Chongqing Science and Technology Committee, Grant/Award Number: cstc2017shmsA130036; Program for Youth Innovation in Future Medicine, Chongqing Medical University, Grant/Award Number: W0063"