Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction

作者全名："Dong, Liang; Fan, Xiaoping; Fan, Yulan; Li, Ximao; Li, Hui; Zhou, Jiying"

作者地址："[Dong, Liang; Fan, Yulan; Li, Hui; Zhou, Jiying] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Fan, Xiaoping] Chongqing Med Univ, Affiliated Hosp 1, Dept Hosp, Chongqing, Peoples R China; [Li, Ximao] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China"

通信作者："Zhou, JY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China."

来源：FRONTIERS IN MOLECULAR NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001026217900001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：migraine; chronification; vestibular dysfunction; functional connectivity; multisensory integration; resting-state functional magnetic resonance

摘要："ObjectivesMigraine is often combined with vestibular dysfunction, particularly in patients with chronic migraine (CM). However, the pathogenesis of migraine chronification leading to vestibular dysfunction is not fully understood. The current study investigated whether structural or functional impairments to the brain during migraine chronification could be associated with vestibular dysfunction development. MethodsThe eligible participants underwent clinical assessment and magnetic resonance imaging (MRI) scans. Voxel-based morphometry (VBM) determined structural impairment by evaluating alterations in gray matter volume (GMV). Functional impairment was assessed by the mean amplitude of low-frequency fluctuation (mALFF). Furthermore, the resting-state functional connectivity (rsFC) of regions possessing impairment was examined with a seed-based approach. We also analyzed the correlations between altered neuroimaging features with clinical variables and performed multiple linear regression. ResultsEighteen CM patients, 18 episodic migraine (EM) patients, and 18 healthy controls (HCs) were included in this study. A one-way ANOVA indicated the group differences in mALFF. These were located within right supramarginal gyrus (SMG), left angular gyrus (AG), middle frontal gyrus (MFG), left middle occipital gyrus (MOG), right rolandic operculum (Rol) and left superior parietal gyrus (SPG). During rsFC analysis, the CM group had more enhanced rsFC of left SPG with left MOG than the EM and HC groups. The EM group revealed enhanced rsFC of left SPG with left AG than the CM and HC groups. In multiple linear regression, after controlling for age, body mass index (BMI) and disease duration, the rsFC of left SPG with left MOG (& beta; = 48.896, p = 0.021) was found to predict the total Dizziness Handicap Inventory (DHI) score with an explained variance of 25.1%. Moreover, the rsFC of left SPG with left MOG (& beta; = 1.253, p = 0.003) and right SMG (& beta; = -1.571, p = 0.049) were significant predictors of migraine frequency, accounting for a total explained variance of 73.8%. ConclusionThe functional impairments due to migraine chronification are primarily concentrated in the multisensory integration-related brain regions. Additionally, the rsFC of SPG with MOG can predict the frequency of migraine and the degree of vestibular dysfunction. Therefore, these neuroimaging features could be potential mechanisms and therapeutic targets for developing vestibular dysfunction in migraine."

基金机构：Science and Technology Planning Project of Yuzhong District of Chongqing City [20210137]

基金资助正文：Funding This work was financially supported by the Science and Technology Planning Project of Yuzhong District of Chongqing City (No. 20210137).