PMAT variant rs3889348 is associated with metformin-induced gastrointestinal among Chinese type 2 diabetes patients

作者全名:"Liu, Ziqing; Jia, Xiao; Wu, Peng; Wu, Benrui; Pan, Ying; Zhong, Shao; Xiao, Luhua; Song, Yuehong; Hu, Jinbo; Zhou, Kaixin"

作者地址:"[Liu, Ziqing; Wu, Benrui] Univ Chinese Acad Sci, Coll Life Sci, Beijing 10140, Peoples R China; [Jia, Xiao] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300000, Peoples R China; [Wu, Peng; Zhou, Kaixin] Guangzhou Lab, Guangzhou, Guangdong, Peoples R China; [Wu, Benrui] Chinese Acad Sci, Natl Lab Biomacromol, Inst Biophys, Beijing 100101, Peoples R China; [Pan, Ying; Zhong, Shao] First peoples Hosp Kunshan, Kunshan, Jiangsu, Peoples R China; [Xiao, Luhua] Kunshan Community Hlth Serv Ctr Bailu, Kunshan, Jiangsu, Peoples R China; [Song, Yuehong] Kunshan Community Hlth Serv Ctr Zhenchuan, Zhenchuan, Jiangsu, Peoples R China; [Hu, Jinbo] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing, Peoples R China"

通信作者:"Zhou, KX (通讯作者),Guangzhou Lab, Guangzhou, Guangdong, Peoples R China."

来源:PHARMACOGENOMICS

ESI学科分类:PHARMACOLOGY & TOXICOLOGY

WOS号:WOS:001026703200001

JCR分区:Q3

影响因子:1.9

年份:2023

卷号:24

期号:10

开始页:551

结束页:560

文献类型:Article

关键词:gastrointestinal; metformin; PMAT; rs3889348; Type 2 diabetes

摘要:"Aim: This study examined intronic gene variants for their association with metformin intolerance in a Chinese population, focusing on the plasma monoamine transporter (PMAT) cis-protein expression quantitative trait loci (cis-eQTL) variant rs3889348. Methods: We recruited type 2 diabetes patients from two hospitals and identified 111 metformin-intolerant patients using a questionnaire, and selected 206 metformin-tolerant patients from 2180 type 2 diabetes mellitus patients. Genetic testing revealed an association between adverse gastrointestinal effects and SLC22A1 and PMAT. Results: The single-nucleotide polymorphism rs3889348 is associated with metformin-induced adverse gastrointestinal effects. Each additional copy of the G allele increases the score by 5.23 (95% CI: 1.82-8.64; p = 0.003). Patients taking more transporter inhibitors were more likely to respond to metformin-induced GI intolerance (p = 0.042). Conclusion: PMAT cis-eQTL rs3889348 was significantly associated with metformin-induced adverse gastrointestinal effects."

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