"Real-World Utilization, Barriers, and Factors Associated With the Targeted Treatment of Metastatic Colorectal Cancer Patients in China: A Multi-Center, Hospital-Based Survey Study"

作者全名："Liu, Yin; Zhang, Xi; Xu, Hui-Fang; Shi, Ji-Hai; Zhao, Yu-Qian; Du, Ling-Bin; Liu, Yun-Yong; Wang, Wen-Jun; Cao, He-Lu; Ma, Li; Huang, Juan-Xiu; Cao, Ji; Li, Li; Fan, Yan-Ping; Gu, Xiao-Fen; Feng, Chang-Yan; Zhu, Qian; Wang, Xiao-Hui; Du, Jing-Chang; Zhang, Jian-Gong; Zhang, Shao-Kai; Qiao, You-Lin"

作者地址："[Liu, Yin; Xu, Hui-Fang; Zhang, Jian-Gong; Zhang, Shao-Kai; Qiao, You-Lin] Zhengzhou Univ, Henan Engn Res Ctr Canc Prevent & Control, Affiliated Canc Hosp,Henan Canc Hosp, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou, Peoples R China; [Zhang, Xi] Peking Univ Canc Hosp & Inst, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing Off Canc Prevent & Control, Beijing, Peoples R China; [Shi, Ji-Hai] Baotou Med Coll, Affiliated Hosp 1, Clin Epidemiol Res Ctr, Dept Dermatol, Baotou, Peoples R China; [Zhao, Yu-Qian] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Sch Med, Chengdu, Peoples R China; [Du, Ling-Bin] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Canc Prevent, Canc Hosp, Hangzhou, Peoples R China; [Liu, Yun-Yong] China Med Univ, Liaoning Canc Hosp & Inst, Liaoning Off Canc Control & Res, Canc Hosp, Shenyang, Peoples R China; [Wang, Wen-Jun] Jining Med Univ, Sch Nursing, Jining, Peoples R China; [Cao, He-Lu] Xinxiang Cent Hosp, Dept Prevent Hlth, Xinxiang, Peoples R China; [Ma, Li] Dalian Med Univ, Publ Hlth Sch, Dalian, Peoples R China; [Huang, Juan-Xiu] Wuzhou Red Cross Hosp, Dept Gastroenterol, Wuzhou, Peoples R China; [Cao, Ji] Guangxi Med Univ, Affiliated Hosp 1, Dept Canc Prevent & Control Off, Nanning, Guangxi, Peoples R China; [Li, Li] Jinan Univ, Affiliated Hosp 1, Dept Clin Res, Guangzhou, Peoples R China; [Fan, Yan-Ping] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Peoples R China; [Gu, Xiao-Fen] Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Student Affairs, Urumqi, Xinjiang, Peoples R China; [Feng, Chang-Yan] Chongqing Univ, Chongqing Key Lab Translat Res Canc Metastasis &, Chongqing, Peoples R China; [Zhu, Qian] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Wang, Xiao-Hui] Gansu Prov Canc Hosp, Dept Publ Hlth, Lanzhou, Peoples R China; [Du, Jing-Chang] Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China; [Qiao, You-Lin] Chinese Acad Med Sci & Peking Union Med Coll, Ctr Global Hlth, Sch Populat Med & Publ Hlth, Beijing, Peoples R China"

通信作者："Zhang, JG; Zhang, SK; Qiao, YL (通讯作者)，Zhengzhou Univ, Henan Engn Res Ctr Canc Prevent & Control, Affiliated Canc Hosp,Henan Canc Hosp, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou, Peoples R China.; Qiao, YL (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Ctr Global Hlth, Sch Populat Med & Publ Hlth, Beijing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001029811500001

JCR分区：Q2

影响因子：2.6

年份：2023

卷号：68

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：associated factors; utilization; barriers; metastatic colorectal cancer; targeted treatment

摘要："Objectives: To explore the utilization, barriers, and factors associated with the targeted treatment of Chinese metastatic colorectal cancer (mCRC) patients.Methods: A total of 1,688 mCRC patients from 19 hospitals in 14 cities were enrolled from March 2020 to March 2021 using stratified, multistage cluster sampling. The use of targeted therapy and any barriers patients experienced were collected. Logistic regression analyses were conducted to identify the factors associated with initiating targeted treatment.Results: About 51.6% of the patients initiated targeted therapy, of whom 44.5%, 20.2%, and 35.2% started first-, second-, and third-line treatment, respectively. The most reported barriers were high medical costs and a lack of belief in the efficacy of targeted therapy. Patients treated in the general hospital, diagnosed at an older age, less educated, and who had a lower family income, no medical insurance, poor health-related quality of life, metastasis outside the liver/lung or systemic metastasis, a shorter duration of mCRC were less likely to initiate targeted therapy.Conclusion: Reduced medical costs and interventional education to improve public awareness could facilitate the use of targeted treatment for mCRC."

基金机构："Beijing Love Book Cancer Foundation; Merck Serono Co., Ltd"

基金资助正文："This research was funded by Beijing Love Book Cancer Foundation. The authors declare that this study received funding from Merck Serono Co., Ltd. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication."