A Prospective Follow-up Study on Risk Factors to Predict the Progression of Unruptured Intracranial Aneurysms on Enhanced

作者全名:"Yang, Cheng-yu; Wen, Li; Cui, Chun; Shu, Tong-sheng; Wang, Zhi-ping; Wang, Guang-xian; Zhang, Dong"

作者地址:"[Yang, Cheng-yu; Wen, Li; Cui, Chun; Shu, Tong-sheng; Wang, Zhi-ping; Zhang, Dong] Army Med Univ, Xinqiao Hosp, Dept Radiol, Chongqing 400037, Peoples R China; [Wang, Guang-xian] Chongqing Med Univ, Banan Peoples Hosp, Dept Radiol, Chongqing 401320, Peoples R China; [Zhang, Dong] Army Med Univ, Xinqiao Hosp, Affiliated Hosp 2, Dept Radiol, Chongqing 400037, Peoples R China"

通信作者:"Zhang, D (通讯作者),Army Med Univ, Xinqiao Hosp, Affiliated Hosp 2, Dept Radiol, Chongqing 400037, Peoples R China."

来源:ACADEMIC RADIOLOGY

ESI学科分类:CLINICAL MEDICINE

WOS号:WOS:001030070100001

JCR分区:Q1

影响因子:3.8

年份:2023

卷号:30

期号:7

开始页:1247

结束页:1256

文献类型:Article

关键词:Aneurysm wall enhancement; Aneurysm size; Unruptured intracranial aneurysm; High-resolution magnetic resonance imaging; Risk factors; Aneurysm progression; Follow-up

摘要:"Rationale and Objectives: To prospectively investigate the potential correlation between qualitative and quantitative assessment of aneurysm wall enhancement (AWE) on initial enhanced high-resolution magnetic resonance imaging (HR-MRI) and aneurysm progression during follow-up.Materials and Methods: From June 2016 to January 2021, we prospectively recruited patients with unruptured intracranial aneurysms (UIAs) for enhanced HR-MRI examination. The patients' demographic and clinical data and aneurysm characteristics, including AWE fea-tures, were collected and analyzed. Follow-up images were compared to evaluate IA progression. Univariate and multivariate Cox propor-tional hazards regression analyses were performed to identify the risk factors associated with aneurysm progression.Results: Seventy-seven patients with 95 UIAs met our research criteria, and the median follow-up time was 15.7 months. Progression was observed in 18 aneurysms; the remaining 77 remained stable. Progressive UIAs were larger in size, more frequently displayed obvious AWE and showed a higher enhancement ratio (ER) than nonprogressive UIAs. Multivariate Cox regression analysis showed that both ER (hazard ratio, 6.304, p < 0.001) and aneurysm size (hazard ratio, 1.343, p = 0.014) were independent risk factors for aneurysm progression. The combination of ER and aneurysm size had an area under the curve of 0.920 for the prediction of aneurysm progression, with a sensi-tivity of 88.9% and specificity of 87.0%. Conclusion: A higher ER value of the aneurysm wall and a larger aneurysm size on initial HR-MRI may predict an increased risk of aneu-rysm progression, which suggests that closer monitoring by imaging or preventive intervention may be required for the clinical manage-ment of these aneurysms."

基金机构:"Joint Project of Science and Health of Chongqing City, China [2021MSXM030, 2023MSXM022]; Talents project of Chongqing, China [CQYC202103075]"

基金资助正文:"This work was supported by the Joint Project of Science and Health of Chongqing City, China (grant number 2021MSXM030, 2023MSXM022) ; and Talents project of Chongqing, China (Dong Zhang) (grant number CQYC202103075) ."