"Correlations between contrast-enhanced CT-measured extracellular volume fraction, histopathological features, and MYCN amplification status in abdominal neuroblastoma: a retrospective study"

作者全名："Wang, Haoru; Ding, Hao; Xie, Mingye; Zhang, Li; Li, Ting; Qin, Jinjie; Chen, Xin; He, Ling"

作者地址："[Wang, Haoru; Ding, Hao; Xie, Mingye; Zhang, Li; Li, Ting; Qin, Jinjie; Chen, Xin; He, Ling] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol, Chongqing Key Lab Pediat,Minist Educ,Key Lab Child, 136 Zhongshan Rd 2, Chongqing 400014, Peoples R China"

通信作者："Chen, X; He, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol, Chongqing Key Lab Pediat,Minist Educ,Key Lab Child, 136 Zhongshan Rd 2, Chongqing 400014, Peoples R China."

来源：ABDOMINAL RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001030505500001

JCR分区：Q2

影响因子：2.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Neuroblastoma; Extracellular matrix; Extracellular volume fraction; Computed tomography

摘要："Purpose To retrospectively investigate the correlations between contrast-enhanced CT (CECT)-measured extracellular volume fraction (fECV) and histopathological features, as well as MYCN amplification status, in abdominal neuroblastoma. Materials and methods One hundred and forty-one patients with abdominal neuroblastoma who underwent CECT scanning were retrospectively enrolled. Calculation of fECV involved the measurement of CT values within regions of interest located within the neuroblastoma and aorta on both non-contrast-enhanced CT and equilibrium CECT. The correlations between fECV and various factors, including pathological subtype, mitosis karyorrhexis index (MKI), Shimada classification, MYCN amplification status, International Neuroblastoma Risk Group (INRG) stage, and risk group were analyzed using either the Mann-Whitney U test or Kruskal-Wallis test. Results Neuroblastoma and ganglioneuroblastoma exhibited fECV values of 0.349 (0.252, 0.424) and 0.438 (0.327, 0.508), respectively, indicating a statistically significant difference (Z = 2.200, P = 0.028). Additionally, the fECV decreased significantly in neuroblastoma with high MKI (H = 8.314, P = 0.016) or unfavorable histology (Z = 3.880, P < 0.001), as well in those with MYCN amplification (Z = 5.486, P < 0.001). Notably, a significant variation in fECV was observed among different INRG stages (H = 16.881, P <0.001) and risk groups (H = 29.014, P < 0.001). Conclusion CECT-derived fECV is associated with histopathological features, MYCN amplification status, INRG stage, and risk stratification of abdominal neuroblastoma, reflecting a potential correlation between the extracellular matrix and the biological behavior of neuroblastoma. [GRAPHICS] ."

基金机构：Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN202000440]

基金资助正文：This study was supported by Scientific and Technological Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202000440).