The pathogenic role of intestinal flora metabolites in diabetic nephropathy

作者全名："Tian, En; Wang, Feng; Zhao, Lei; Sun, Yan; Yang, Jurong"

作者地址："[Tian, En; Zhao, Lei; Sun, Yan; Yang, Jurong] Chongqing Med Univ, Affiliated Hosp 3, Chongqing, Peoples R China; [Wang, Feng] Beibei Tradit Chinese Med Hosp, Chongqing, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Chongqing, Peoples R China."

来源：FRONTIERS IN PHYSIOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001031408400001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：diabetic nephropathy; gut microbes; metabolites; novel therapeutics; therapeutic targets

摘要："With the increasing incidence of diabetes, diabetic kidney disease has become a major cause of chronic kidney disease. The role of the gut microbiota in diabetes and its related complications have been extensively investigated; the modulatory effect of the gut microbiota on the host depends on several gut microbial metabolites, particularly short-chain fatty acids, secondary bile acids, and trimethylamine N-oxide. In this review, we focused on the evidence related to the pathogenic role of each of the gut microbial metabolites in diabetic nephropathy. The main novel therapies targeting the gut microbiota include probiotics, dietary prebiotics, synbiotic supplements, and faecal microbiota transplants, although there is no standard treatment principle. Further research is therefore needed to elucidate the link between gut microbes and diabetic nephropathy, and more therapeutic targets should be explored to treat diabetic nephropathy with dysbiosis of the gut microbes."

基金机构：National Natural Science Foundation of China [82270723]; Chongqing Talent Program Project [cstc2021ycjh-bgzxm0090]

基金资助正文："& nbsp;This research was funded by the National Natural Science Foundation of China (No. 82270723), and the Chongqing Talent Program Project (cstc2021ycjh-bgzxm0090)."