Significance of marginal vessels in differentiating peripheral small-cell lung cancer and benign lung tumor

作者全名："Zhang, Xiao-chuan; Lv, Fa-jin; Fu, Bin-jie; Liang, Zhang-rui; Chu, Zhi-gang"

作者地址："[Zhang, Xiao-chuan; Lv, Fa-jin; Fu, Bin-jie; Liang, Zhang-rui; Chu, Zhi-gang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Zhang, Xiao-chuan] Chonggang Gen Hosp, Dept Radiol, Chongqing, Peoples R China; [Chu, Zhi-gang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1, Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Chu, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1, Youyi Rd, Chongqing 400016, Peoples R China."

来源：ACTA RADIOLOGICA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001032385400001

JCR分区：Q3

影响因子：1.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Small cell lung carcinoma; X-ray computed tomography; lung neoplasms; differential diagnosis

摘要："Background Some peripheral small cell lung cancers (pSCLCs) and benign lung tumors (pBLTs) have similar morphological features but different treatment and prognosis. Purpose To determine the significance of marginal vessels in differentiating pSCLCs and pBLTs. Material and Methods A total of 57 and 95 patients with pathological confirmed nodular (& LE;3 cm) pSCLC and pBLT with similar morphological features were enrolled in this study retrospectively. The patients' clinical characteristics and computed tomography (CT) features of tumors and marginal vessels (vessels connecting with tumors) were analyzed and compared. Results Compared with pBLTs, pSCLCs had a larger diameter (P = 0.001) but lower enhancement (P = 0.015) and fewer had calcification (P = 0.013). Compared with pBLTs, more lesions had proximal (70.2% vs. 22.1%) and distal (59.6% vs. 4.2%) marginal vessels in pSCLCs (each P < 0.0001). In addition, in pSCLCs, the numbers of proximal (1.3 & PLUSMN; 1.4 vs. 0.3 & PLUSMN; 0.6), distal (2.4 & PLUSMN; 3.1 vs. 0.1 & PLUSMN; 0.5), and total (3.6 & PLUSMN; 3.5 vs. 0.4 & PLUSMN; 1.0) marginal vessels were all more than those in pBLTs (each P < 0.001). Receiver operating characteristic curve analysis revealed the positive distal marginal vessel sign had the highest specificity (95.8%), and the number of total marginal vessels had the best performance in discriminating pSCLC from pBLT (cutoff value = 1.5, AUC = 0.80, 95% CI = 0.72-0.89, sensitivity = 70.2%, and specificity = 91.6%). Conclusion For peripheral solid nodules similar to pBLTs but without any calcification, the possibility of pSCLC should be considered if they have multiple marginal vessels (& GE;2), especially the distal ones."

基金机构：Joint Project Chongqing Science and Technology Commission and Chongqing Public Health Commission [2022MSXM050]

基金资助正文："The author(s) disclosed receipt of the followingfinancial supportfor the research, authorship, and/or publication of this article:This work was supported by the Joint Project ChongqingScience and Technology Commission and Chongqing PublicHealth Commission (grant number 2022MSXM050"