High expression of RPL27A predicts poor prognosis in patients with hepatocellular carcinoma

作者全名："Xing, Huiwu; Jiang, Xiangqi; Yang, Chenyu; Tan, Bingqian; Hu, Jiqiang; Zhang, Mingman"

作者地址："[Xing, Huiwu; Jiang, Xiangqi; Yang, Chenyu; Tan, Bingqian; Hu, Jiqiang; Zhang, Mingman] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Hepatobiliary Surg, Chongqing Key Lab Pediat,Childrens Hosp,Minist Edu, Chongqing 400010, Peoples R China"

通信作者："Zhang, MM (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Hepatobiliary Surg, Chongqing Key Lab Pediat,Childrens Hosp,Minist Edu, Chongqing 400010, Peoples R China."

来源：WORLD JOURNAL OF SURGICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001032884700001

JCR分区：Q1

影响因子：2.5

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：HCC; RPL27A; Prognosis; Co-expression genes; Immune infiltration

摘要："BackgroundHepatocellular carcinoma (HCC) is one of the most common cancers in the digestive system with rapid progression and poor prognosis. Recent studies have shown that RPL27A could be used as a biomarker for a variety of cancers, but its role in HCC is not clear.MethodWe analyzed the expression of RPL27A in the pan-cancer analysis and analyzed the relationship between the expression of RPL27A and the clinical features and prognosis of patients with HCC. We evaluated the expression difference of RPL27A in HCC tissues and paired normal adjacent tissues using immunohistochemistry. Furthermore, we analyzed the co-expression genes of RPL27A and used them to explore the possible mechanism of RPL27A and screen hub genes effecting HCC. In addition, we studied the role of RPL27A in immune infiltration and mutation.ResultsWe found that the expression level of RPL27A increased in a variety of cancers, including HCC. In HCC patients, the high expression of RPL27A was related to progression and poor prognosis as an independent predictor. We also constructed a protein interaction network through co-expression gene analysis of RPL27A and screened 9 hub genes. Enrichment analysis showed that co-expression genes were associated with ribosome pathway, viral replication, nuclear-transcribed mRNA catabolic process, and nonsense-mediated decay. We found that the expression level of RPL27A was closely related to TP53 mutation and immune infiltration in HCC.ConclusionRPL27A might become a biomarker in the diagnosis, treatment, and follow-up of patients with HCC."

基金机构：Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX1023]

基金资助正文：This work was supported by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX1023)