C-Reactive Protein Levels and Cognitive Decline following Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

作者全名："Wang, Likun; Yang, Lining; Liu, Haiyan; Pu, Juncai; Li, Yi; Tang, Lu; Chen, Qing; Pu, Fang; Bai, Dingqun"

作者地址："[Wang, Likun; Yang, Lining; Liu, Haiyan; Li, Yi; Tang, Lu; Chen, Qing; Bai, Dingqun] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China; [Pu, Juncai] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Pu, Fang] Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China"

通信作者："Bai, DQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China.; Pu, F (通讯作者)，Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China."

来源：BRAIN SCIENCES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001035051900001

JCR分区：Q3

影响因子：2.7

年份：2023

卷号：13

期号：7

开始页：　

结束页：　

文献类型：Review

关键词：cognition; C-reactive protein; inflammatory factor; meta-analysis; cognitive decline; ischemic stroke

摘要："Cognitive decline (CD) is devastating with a high incidence in patients after stroke. Although some studies have explored underlying associations between C-reactive protein (CRP) levels and cognitive decline after stroke, consistent results have not been obtained. Therefore, this meta-analysis aimed to explore whether or not higher levels of C-reactive proteins were associated with an increased risk of cognitive decline after stroke. To this end, PubMed, Embase, the Cochrane Library, and Web of Science were searched for eligible studies, and pooled effect sizes from eligible studies were calculated using random effect models. Furthermore, subgroups were established and meta-regression analyses were performed to explain the causes of heterogeneity. Eventually, nine studies with 3893 participants were included. Our statistical results suggested that the concentrations of peripheral CRP may be significantly increased for CD patients after stroke, compared to those of non-CD patients. Subgroup analyses showed that CRP was higher in CD than that in non-CD patients when the mini-mental state examination was used. A higher level of CRP in the acute phase of ischemic stroke may suggest an increased risk of CD after stroke. However, these results should be cautiously interpreted because of the limited sample sizes and the diversity of potential confounders in the studies included in this meta-analysis."

基金机构：National Key Research and Development Program of China [2020YFC2005900]; National Natural Science Foundation of China [82002396]; Program for Innovation Team Building at Institutions of Higher Education in Chongqing [CXQT21018]; In-Hospital Cultivation Fund of the First Affiliated Hospital of Chongqing Medical University [PYJJ2021-07]; Intelligent Medicine Research Project of Chongqing Medical University [YJSZHYX202109]

基金资助正文：This research was funded by the National Key Research and Development Program of China (grant no. 2020YFC2005900); the National Natural Science Foundation of China (grant no. 82002396); Program for Innovation Team Building at Institutions of Higher Education in Chongqing (grant CXQT21018); In-Hospital Cultivation Fund of the First Affiliated Hospital of Chongqing Medical University (grant no. PYJJ2021-07); the Intelligent Medicine Research Project of Chongqing Medical University (grant no. YJSZHYX202109).