Spectral Analysis Based on Hemodynamic Habitat Imaging Predicts Isocitrate Dehydrogenase Status and Prognosis in High-Grade Glioma

作者全名："Qiao, Jinguo; Wu, Hao; Liu, Jiachen; Kang, Houyi; Wang, Shunan; Fang, Jingqin; Zhang, Junfeng; Zhang, Weiguo"

作者地址："[Qiao, Jinguo; Liu, Jiachen; Kang, Houyi; Wang, Shunan; Fang, Jingqin; Zhang, Weiguo] Army Med Univ, Daping Hosp, Dept Radiol, Chongqing, Peoples R China; [Qiao, Jinguo; Liu, Jiachen; Kang, Houyi; Wang, Shunan; Fang, Jingqin; Zhang, Weiguo] Chongqing Clin Res Ctr Imaging & Nucl Med, Chongqing, Peoples R China; [Wu, Hao] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Zhang, Junfeng] Gen Hosp Western Theater Command PLA, Dept Radiol, Chengdu, Sichuan, Peoples R China"

通信作者："Zhang, WG (通讯作者)，Army Med Univ, Daping Hosp, Dept Radiol, Chongqing, Peoples R China.; Zhang, WG (通讯作者)，Chongqing Clin Res Ctr Imaging & Nucl Med, Chongqing, Peoples R China."

来源：WORLD NEUROSURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001035812200001

JCR分区：Q2

影响因子：1.9

年份：2023

卷号：175

期号：　

开始页：E520

结束页：E530

文献类型：Article

关键词：Habitat imaging; High-grade glioma; Hemodynamic tissue signature; Heterogeneity; IDH status; Spectral analysis; Prognosis

摘要："-BACKGROUND: The intratumoral heterogeneity of high-grade gliomas (HGGs) is associated with isocitrate dehydro-genase (IDH) status and prognosis, which can be established by quantitative radioanalysis of spatial tumor habitats. Therefore,we designed a framework for tackling tumors based on spatial metabolism using the hemodynamic tissue signa-ture (HTS), focusing on metabolic changes in tumor habitat to predict IDH status and assess prognosis in patients with HGG. -METHODS: Preoperative data for 121 patients with HGG with subsequent histologic confirmation of HGG were pro-spectively collected (January 2016 to December 2020). The HTS was mapped from the image data, chemical shift im-aging voxels were selected from the HTS habitat as the region of interest, and the metabolic ratio of the HTS was calculated using weighted least square method fitting. The metabolic rate of the tumor enhancement area was used as a control to analyze the efficacy of each HTS metabolic rate in predicting the IDH status and prognosis of HGG.- RESULTS: Total choline (Cho)/total creatine and Cho/ N-acetyl-aspartate showed significant differences between IDH-wildtype and IDH-mutant in high- and lowangiogenic enhanced tumor sites (P < 0.05); Cho/total creatine was an independent risk factor for prognosis of HGG patients in high-angiogenic enhanced tumor habitats, with significant differences in survival time between groups (P < 0.05). The metabolic ratio in the tumor enhanced area could not predict IDH status or evaluate prognosis.- CONCLUSIONS: Spectral analysis based on hemodynamic habitat imaging can clearly distinguish IDH mutations and the prognosis assessment is more accurate, rendering it superior to traditional spectral analysis in tumor enhancement areas."

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