Vaccination against COVID-19 and potential protective effects on seizure recurrence in children with epilepsy: A cross-sectional survey

作者全名："Chen, Congjie; Chen, Ningning; Xie, Li; Luo, Yuanyuan; Ma, Jiannan; Li, Tingsong"

作者地址："[Chen, Congjie; Chen, Ningning; Xie, Li; Li, Tingsong] Childrens Hosp Chongqing Med Univ CHCMU, Dept Rehabil, Bldg 8,Zhongshan Er Rd 136, Chongqing 400014, Peoples R China; [Chen, Congjie; Chen, Ningning; Xie, Li; Luo, Yuanyuan; Ma, Jiannan; Li, Tingsong] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Chen, Congjie; Chen, Ningning; Xie, Li; Luo, Yuanyuan; Ma, Jiannan; Li, Tingsong] Natl Clin Res Ctr Child Hlth & Disorders Chongqing, Chongqing, Peoples R China; [Chen, Congjie; Chen, Ningning; Xie, Li; Luo, Yuanyuan; Ma, Jiannan; Li, Tingsong] Int Sci & Technol Cooperat Base Child Dev & Crit D, Chongqing, Peoples R China; [Chen, Congjie; Chen, Ningning; Xie, Li; Luo, Yuanyuan; Ma, Jiannan; Li, Tingsong] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Luo, Yuanyuan; Ma, Jiannan] CHCMU, Dept Neurol, Chongqing, Peoples R China"

通信作者："Li, TS (通讯作者)，Childrens Hosp Chongqing Med Univ CHCMU, Dept Rehabil, Bldg 8,Zhongshan Er Rd 136, Chongqing 400014, Peoples R China."

来源：EPILEPSIA OPEN

ESI学科分类：　

WOS号：WOS:001036288100001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：children; COVID-19; epilepsy; vaccine

摘要："ObjectiveDespite strong evidence on the safety and tolerability of the COVID-19 vaccine, data on vaccination in children with epilepsy, particular younger children with specific epilepsy syndromes, are limited. The protective effects of vaccination against seizure increase upon COVID-19 infection also remain to be elucidated. MethodsQuestionnaire surveys were distributed online via an established WeChat group for patient management as well as in our outpatient clinic. The data collected included demographics and clinical information related to COVID-19 vaccination and infection. Detailed information related to epilepsy diagnosis and treatment was also collected from our patient database. Logistic regression analysis was performed to determine the factors associated with non-vaccination. The characteristics of seizures following COVID-19 infection were described. ResultsIn total, 354 suitable questionnaires were included in the study. The median age at survey was 6 years (interquartile range 4, 9). The most common epilepsy syndrome was self-limited epilepsy (n = 153, 43.2%), followed by developmental and/or epileptic encephalopathy (D/EE, n = 81, 22.9%) and genetic generalized epilepsy (n = 59, 16.7%). The vaccine uptake rate was 43.8% (n = 155), and all related side-effects (n = 11, 7.1%) remitted spontaneously. Younger age (odds ratio [OR] = 0.877, P = 0.001), D/EE (OR = 5.096, P = 0.008), and less than six months seizure-freedom before vaccination (OR = 3.026, P = 0.005) were associated with unwillingness to be vaccinated. There were no significant differences in the rate of COVID-19 infection (33.7% vs 32.7%, P = 0.879) and resultant increased seizure activity following infection between the vaccinated and unvaccinated groups after propensity score matching (9.1% vs 15.6%, P = 0.428).Three unvaccinated cases of Dravet syndrome developed status epilepticus following COVID-19 infection. SignificanceVaccination against COVID-19 is safe and well tolerated in children, even in younger patients with D/EE. Although the risk of worsening seizures following COVID-19 infection may not be reduced by immunization, education focused on increased vaccination in pediatric epilepsy is still warranted."

基金机构：CQMU Program for Youth Innovation in Future Medicine [W0031]

基金资助正文：ACKNOWLEDGMENTs This study was supported by CQMU Program for Youth Innovation in Future Medicine (W0031).