Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection

作者全名："Xie, Qinli; He, Yangjun; Zhou, Danni; Jiang, Yi; Deng, Ying; Li, Ruoqing"

作者地址："[Xie, Qinli] Chongqing Univ, Dept Phys Examinat Ctr, Chongqing Emergency Med Ctr, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China; [He, Yangjun] Chongqing Univ, Chongqing Emergency Med Ctr, Dept Emergency, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China; [Zhou, Danni] Chongqing Med Univ, Ctr Reprod Med, Chongqing Hlth Ctr Women & Children, Women & Childrens Hosp, Chongqing, Peoples R China; [Jiang, Yi; Li, Ruoqing] Chongqing Univ, Chongqing Emergency Med Ctr, Dept Gen Med, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China; [Deng, Ying] Chongqing Univ, Chongqing Emergency Med Ctr, Dept Plast Surg, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China"

通信作者："Li, RQ (通讯作者)，Chongqing Univ, Chongqing Emergency Med Ctr, Dept Gen Med, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China.; Deng, Y (通讯作者)，Chongqing Univ, Chongqing Emergency Med Ctr, Dept Plast Surg, Chongqing Key Lab Emergency Med,Cent Hosp, Chongqing, Peoples R China."

来源：PEERJ

ESI学科分类：Multidisciplinary

WOS号：WOS:001037334200003

JCR分区：Q2

影响因子：2.3

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Metabolic syndrome; Helicobacter pylori; Insulin resistance; Inflammatory factors

摘要："Background: Globally, metabolic syndrome (MS) and Helicobacter pylori (HP) infection, which have gained an epidemic status, are major challenges to human health, society, and medical professionals. Recent studies have demonstrated that MS is closely related to HP infection. Additionally, HP is an important risk factor for gastric cancer. However, systematic reviews on HP are lacking. This review aimed to summarize and analyze the potential correlation of HP infection with MS and its components, as well as the underlying mechanism, to provide reference and strategies for clinical prevention and treatment. Methodology: Previous studies examining the correlation between HP and MS since 1990 were retrieved from the PubMed, Web of Science, and Embase databases. The potential correlation between HP infection and MS and its components was comprehensively analyzed. The keywords ""Helicobacter pylori,"" ""HP,"" ""metabolic syndrome,"" ""hypertension,"" ""obesity,"" ""diabetes,"" or ""dyslipidemia"" were used in all fields. No language restrictions were imposed. Results: MS was strongly correlated to HP infection. The inflammatory response and inflammatory factors produced during HP infection are important etiological factors for insulin resistance and MS. The co-occurrence of long-term chronic inflammation and immune dysfunction with MS may be the predisposing factor for HP infection. MS components, such as diabetes, hypertension, dyslipidemia, and obesity were also correlated with HP infection in one or both directions. Conclusions: HP infection and MS may promote the pathogenesis of each other. The contribution of HP infection and MS to gastric cancer cannot be ruled out based on co-occurrence. The MS components diabetes and obesity may be bidirectionally correlated with HP infection."

基金机构："Joint Medical Research Project of Chongqing Municipal Science and the Technology Bureau and Health Commission [2023QNXM044]; Chongqing Municipal Science and Technology Bureau and Health Commission [2023QNXM044]; Scientific research project of Chongqing Municipal Sports Bureau [C202108, C202202, C202206]; Chongqing Key Laboratory of Emergency Medicine [2022KFKT03]"

基金资助正文："This work was supported by the Joint Medical Research Project of Chongqing Municipal Science and the Technology Bureau and Health Commission (2023QNXM044) , the Scientific research project of Chongqing Municipal Sports Bureau (C202108,C202202, C202206) , and the Chongqing Key Laboratory of Emergency Medicine (2022KFKT03) . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."