TMEM41A overexpression correlates with poor prognosis and immune alterations in patients with endometrial carcinoma

作者全名："Shi, Ke; Liu, Xiao-Li; Guo, Qiang; Zhang, Yun-Qiang; Fan, Si-Tong; Dai, Ling; Jiang, Ni; Li, Dan"

作者地址："[Shi, Ke; Zhang, Yun-Qiang] Beilun Dist Peoples Hosp Ningbo, Dept Thorac Surg, Ningbo, Peoples R China; [Liu, Xiao-Li] Peoples Hosp Jianyang City, Dept Ultrasound, Jianyang City, Peoples R China; [Guo, Qiang] Hubei Med Univ, Taihe Hosp, Dept Cardiothorac Surg, Shiyan, Peoples R China; [Fan, Si-Tong] Beilun Dist Peoples Hosp Ningbo, Dept Infect Dis, Ningbo, Peoples R China; [Dai, Ling; Jiang, Ni] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing, Peoples R China; [Li, Dan] Hubei Med Univ, Taihe Hosp, Dept Oncol, Shiyan, Peoples R China"

通信作者："Dai, L; Jiang, N (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing, Peoples R China.; Li, D (通讯作者)，Hubei Med Univ, Taihe Hosp, Dept Oncol, Shiyan, Peoples R China."

来源：PLOS ONE

ESI学科分类：Multidisciplinary

WOS号：WOS:001038283600048

JCR分区：Q1

影响因子：2.9

年份：2023

卷号：18

期号：7

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结束页：　

文献类型：Article

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摘要："BackgroundExpression levels of transmembrane protein 41A (TMEM41A) are related to the progression of malignant tumors. However, the association between TMEM41A expression and endometrial carcinoma (EC) remains unclear. This study aims to identify the roles of TMEM41A expression in the prognosis of patients with EC and its correlation with EC progression. MethodsThe TMEM41A expression and its correlation with the survival of patients with EC were assessed. Cox regression analysis was used to identify the prognostic factors, while nomograms were used to examine the association between the prognostic factors and the survival of patients with EC. Finally, the link between TMEM41A level and immune microenvironment and RNA modifications was investigated in EC. ResultsTMEM41A was overexpressed in EC. TMEM41A overexpression could diagnose the EC and evaluate the poor prognosis of patients. Overexpression of TMEM41A was associated with clinical stage, age, weight, histological subtype, tumor grade, and survival status of patients with EC. Clinical stage, age, tumor grade, radiotherapy, and TMEM41A overexpression were factors of poor prognosis in patients with EC. The nomograms revealed the correlation between the TMEM41A level and survival time of patients with EC at 1, 3, and 5 years. Furthermore, TMEM41A overexpression was significantly correlated with the level of the stromal score, immune score, estimate score, NK CD56 bright cells, iDC, NK cells, eosinophils, pDC, T cells, TReg, cytotoxic cells, mast cells, Th17 cells, neutrophils, aDC, NK CD56 dim cells, TFH, Th2 cells, CD8 T cells, macrophages, immune cell markers, and RNA modifications. ConclusionsTMEM41A is overexpressed in EC tissues and is associated with the prognosis, immune microenvironment, and RNA modification. Our preliminary studies indicate that overexpression of TMEM41A can potentially serve as a biomarker for EC treatment."

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