Defining RSV epidemic season in southwest China and assessing the relationship between birth month and RSV infection: A 10-year retrospective study from June 2009 to May 2019

作者全名："Li, Taoyu; Fang, Heping; Liu, Xiangyu; Deng, Yu; Zang, Na; Xie, Jun; Xie, Xiaohong; Luo, Zhengxiu; Luo, Jian; Liu, Yulin; Fu, Zhou; Ren, Luo; Liu, Enmei"

作者地址："[Li, Taoyu; Fang, Heping; Liu, Xiangyu; Deng, Yu; Zang, Na; Xie, Jun; Xie, Xiaohong; Luo, Zhengxiu; Luo, Jian; Liu, Yulin; Fu, Zhou; Ren, Luo; Liu, Enmei] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Resp Med,Key Lab Child Dev & Disorders,Minist, 136 Zhongshan 2nd Rd, Chongqing, Peoples R China; [Li, Taoyu; Fang, Heping; Liu, Xiangyu; Ren, Luo] Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Chongqing, Peoples R China"

通信作者："Ren, L; Liu, EM (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Resp Med,Key Lab Child Dev & Disorders,Minist, 136 Zhongshan 2nd Rd, Chongqing, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001038390400040

JCR分区：Q1

影响因子：6.8

年份：2023

卷号：95

期号：7

开始页：　

结束页：　

文献类型：Article

关键词：infant; respiratory syncytial virus; respiratory tract infections; season

摘要："Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections (LRTI). However, only limited information is available regarding its seasonality and its relationship with birth month. A retrospective hospital-based study was carried out from June 2009 to May 2019 in Chongqing, southwest of China. LRTI cases under 5 years were enrolled in this study and PCR was used to detect 8 respiratory viruses. RSV seasonality was determined using ""average annual percentage"" (AAP) and ""percent positivity"" method. A total of 6991 cases were enrolled in this study, with an RSV positivity of 34.5%. From June 2009 to May 2019, we analyzed RSV epidemic season during 10 RSV epidemic years in Chongqing using two methods. The result of AAP method was similar to that of percent positivity method with a 30% threshold, which showed an epidemic season of roughly October to March in the subsequent year, with a small peak in June. On average, the RSV epidemic season in RSV-A dominant years typically started earlier (week 42 for RSV-A vs. week 46 for RSV-B), ended earlier (week 12 for RSV-A vs. week 14 for RSV-B), lasted longer (24 weeks for RSV-A vs. 22 weeks for RSV-B), and reached its peak earlier (week 2 for RSV-A vs. week 3 for RSV-B) than in RSV-B dominant years. The proportion of severe LRTI was higher in cases of single infection with RSV-A compared to those of single infection with RSV-B (26.3% vs. 22.3%, p = 0.024). Among infants under 1 year, those born in May and August through December were more likely to be infected with RSV. Infants born 1-2 months before the epidemic season were relatively more susceptible to RSV infection. In Chongqing, the RSV epidemic was seasonal and usually lasted from October to March of next year with a small peak in summer. Infants born 1-2 months before the epidemic season were relatively more susceptible to RSV infection and this population should be targeted while developing RSV immunization strategies."

基金机构：National Key Research and Development Program of China [2022YFC2704900]; Sanofi [RSV00032]

基金资助正文："National Key Research and Development Program of China, Grant/Award Number: 2022YFC2704900; Sanofi, Grant/Award Number: RSV00032"