Synthesis of gold Nanoparticles Encapsulated Chitosan/Gelatin Polymers for the Treatment of Several Types of Leukemia

作者全名："Ma, Yanmei; He, Fuxiang; El-kott, Attalla F.; Alshehri, Ali S.; Zein, Mohamed Abdellatif; Eldib, Ali M."

作者地址："[Ma, Yanmei] Changzhi Med Coll, Dept Hematol & Oncol, Heji Hosp, Changzhi 046011, Peoples R China; [He, Fuxiang] Chongqing Med Univ, Dept Emergency, Childrens Hosp, Chongqing 400010, Peoples R China; [El-kott, Attalla F.; Alshehri, Ali S.] King Khalid Univ, Coll Sci, Biol Dept, Abha 61421, Saudi Arabia; [El-kott, Attalla F.; Eldib, Ali M.] Damanhour Univ, Fac Sci, Zool Dept, Damanhour 22511, Egypt; [Zein, Mohamed Abdellatif] Univ Coll AlWajh, Univ Tabuk, Chem Dept, Tabuk, Saudi Arabia; [Zein, Mohamed Abdellatif] Damanhour Univ, Fac Sci, Chem Dept, Damanhour, Egypt; [Eldib, Ali M.] Alrayan Med Coll, Coll Med, Hejrah St Madinah,POB 41411, Almadinah, Saudi Arabia"

通信作者："He, FX (通讯作者)，Chongqing Med Univ, Dept Emergency, Childrens Hosp, Chongqing 400010, Peoples R China."

来源：JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS

ESI学科分类：CHEMISTRY

WOS号：WOS:001038592000001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Chitosan; Gelatin; Au NPs; Leukemia; MTT; Cytotoxicity

摘要："We herein demonstrate the biogenic nano-architechtonics of gold nanoparticles template over chitosan/gelatin mixed hydrogel having excellent reducing ability. The two biopolymers, i.e., chitosan and gelatin also had the capacity to stabilize as-synthesized Au NPs. Physicochemical and structural features of the nanocomposite biomaterial was assessed by several techniques like FT-IR, SEM, TEM, EDX and XRD. TEM study revealed the mean diameter of the spherical shaped Au NPs/CS-Gel material was in the range of 10-15 nm. Thereafter, the Au NPs/CS-Gel bio-composite material was exploited in the study of cytotoxicity and anti-leukemia effects against diverse leukemia cell lines like acute myeloid leukemia (32D-FLT3-ITD and Human HL-60/vcr), acute lymphoblastic leukemia (MOLT-3 and TALL-104), and acute T cell leukemia (Jurkat, Clone E6-1 and J.RT3-T3.5) in situ. Interestingly, the nano-drug could resist significantly against those cell lines in a time and concentration-dependent manner, assessed by MTT method. The corresponding IC50 values of the bio-composite were 341, 500, 417, 407, 389, and 500 & mu;g/mL respectively against the cell lines."

基金机构：Deanship of Scientific Research at King Khalid University [RGP2/232/44]

基金资助正文：AcknowledgementsThe authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through large groups under grant number RGP2/232/44.