The prospective study of 54 children with electrical status epilepticus during sleep: How to simplify the electroencephalogram diagnosis and guide the treatment

作者全名："Zhang, Han; Yan, Lisi; Peng, Xiaoling; Jiang, Li; Zhang, Junjiao; Chen, Jin; Hu, Yue"

作者地址："[Zhang, Han; Yan, Lisi; Jiang, Li; Zhang, Junjiao; Chen, Jin; Hu, Yue] Chongqing Med Univ, Dept Neurol, Childrens Hosp, Chongqing, Peoples R China; [Zhang, Han; Yan, Lisi; Jiang, Li; Zhang, Junjiao; Chen, Jin; Hu, Yue] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Zhang, Han; Yan, Lisi; Jiang, Li; Zhang, Junjiao; Chen, Jin; Hu, Yue] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Zhang, Han; Yan, Lisi; Jiang, Li; Zhang, Junjiao; Chen, Jin; Hu, Yue] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Zhang, Han; Yan, Lisi; Jiang, Li; Zhang, Junjiao; Chen, Jin; Hu, Yue] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Peng, Xiaoling] Beijing Normal Univ, Hong Kong Baptist Univ United Int Coll, Div Sci & Technol, Zhuhai, Peoples R China; [Hu, Yue] Chongqing Med Univ, Dept Neurol, Childrens Hosp, Chongqing 400136, Peoples R China"

通信作者："Hu, Y (通讯作者)，Chongqing Med Univ, Dept Neurol, Childrens Hosp, Chongqing 400136, Peoples R China."

来源：EPILEPTIC DISORDERS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001039307300001

JCR分区：Q3

影响因子：1.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：electrical status epilepticus during sleep; electroencephalogram; high-frequency oscillations; spike-wave index; treatment

摘要："Objective: To simplify the electroencephalogram (EEG) diagnosis and guide the treatment of electrical status epilepticus during sleep (ESES).Methods: We recruited 54 children with ESES from December 2019 to December 2020 and compared various spike-wave index (SWI) calculation methods. Time-frequency analysis assessed the correlation between high-frequency oscillations energy and the SWI. We divided 42 children into responder and non-responder treatment groups based on the observations made during a 12-month follow-up period and evaluate different treatment and the independent risk factors of refractory ESES.Results: The SWI of 5 min before the second sleep cycle of non-rapid eye movement (NREM; long method II) and that of all NREM sleep (total method) were not significantly different (p = .06). The average energy of ? (r = .288, p = .002) and ripple (r = .203, p = .04) oscillations were correlated with the SWI. Multivariable logistic regression analysis showed that encephalomalacia was an independent risk factor for refractory ESES (OR: 10.48, 95% CI: 1.62-67.63). The clinical seizure improvement rates of anti-seizure medications (ASMs), ASMs with benzodiazepines, and ASMs with benzodiazepines and steroids after 12 months were 9.3%, 42.8%, and 53.8%, EEG improvement rate were 5.5%, 30.9% and 37%, respectively. The intelligence of the children in the responder treatment group has improved during the 1-year follow-up.Significance: These findings demonstrate EEG and clinical features of ESES and may provide basis for simplifying diagnosis and guiding the treatment of children with ESES."

基金机构：Chongqing Science and Health Joint Medical Research Project [2023MSXM137]

基金资助正文：ACKNOWLEDGMENTS The authors would like to thank all participants for their cooperation and Xiaoling Peng for her statistics assistance.This study was funded by the Chongqing Science and Health Joint Medical Research Project (Grant 2023MSXM137). The funding source had no direct involvement in the conduct of the study.