The ketogenic diet for Dravet syndrome: A multicenter retrospective study

作者全名："Yu, Mei; Li, Hua; Sun, Dan; Li, Dan; Zhong, Jianmin; Gu, Qiang; Huang, Shaoping; Luo, Rong; Zhu, Dengna; Yuan, Baoqiang; Li, Baomin; Xiao, Nong; Chen, Yucai; Zhang, Yuqin; Wei, Jurong; Jiang, Yuwu; Liao, Jianxiang; Qin, Jiong"

作者地址："[Yu, Mei; Liao, Jianxiang] Shenzhen Childrens Hosp, Dept Neurol, Shenzhen, Peoples R China; [Li, Hua] Guangdong 999 Brain Hosp, Dept Epilepsy Ctr, Guangzhou, Peoples R China; [Sun, Dan] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Neurol, Wuhan, Peoples R China; [Li, Dan; Huang, Shaoping] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Neurol, Xian, Peoples R China; [Zhong, Jianmin] Jiangxi Prov Childrens Hosp, Dept Neurol, Nanchang, Peoples R China; [Gu, Qiang; Jiang, Yuwu] Peking Univ First Hosp, Dept Pediat Neurol, Beijing, Peoples R China; [Luo, Rong] Sichuan Univ, West China Univ Hosp 2, Dept Neurol, Chengdu, Peoples R China; [Zhu, Dengna] Zhengzhou Univ, Affiliated Hosp 3, Dept Neurol, Zhengzhou, Peoples R China; [Yuan, Baoqiang] Xuzhou Med Univ, Affiliated Hosp, Dept Neurol, Xuzhou, Peoples R China; [Li, Baomin] Shandong Univ, Qilu Hosp, Dept Neurol, Jinan, Peoples R China; [Xiao, Nong] Chongqing Med Univ, Dept Neurol, Childrens Hosp, Chongqing, Peoples R China; [Chen, Yucai; Wei, Jurong] Childrens Hosp Shanghai, Dept Neurol, Shanghai, Peoples R China; [Zhang, Yuqin] Tianjin Childrens Hosp, Dept Neurol, Tianjin, Peoples R China; [Qin, Jiong] Peking Univ Peoples Hosp, Dept Neurol, Beijing, Peoples R China"

通信作者："Liao, JX (通讯作者)，Shenzhen Childrens Hosp, Dept Neurol, Shenzhen, Peoples R China.; Jiang, YW (通讯作者)，Peking Univ First Hosp, Dept Pediat Neurol, Beijing, Peoples R China.; Qin, J (通讯作者)，Peking Univ Peoples Hosp, Dept Neurol, Beijing, Peoples R China."

来源：NUTRITION

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001039768500001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：110

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Epilepsy; Dravet syndrome; Ketogenic diet; Effective rate; Adverse events

摘要："Objective: The ketogenic diet (KD) is one of the main treatments for drug-resistant epilepsy. However, there have been few multicenter reports on the use of the KD for the treatment of Dravet syndrome (DS). The aim of this study was to analyze the efficacy and safety of this approach based on a large number of multicenter cases. Methods: This was a retrospective, multicenter cohort study from 14 centers in China. All patients were treated with the KD. We compared the effects of KD intervention time, age, and other factors.Results: From March 2014 to March 2020, we treated 114 patients with DS with the KD. The male-to-female ratio was 67:47. The KD median initiation age was 3 y and 4 mo, and the median number of antiseizure med-ications (ASMs) was 2.4. KD therapy was the first choice for three patients. Exactly 10.5% of the patients started KD therapy after failure of the first ASM therapy, with 35.1% after failure of the second, 44.7% after the third, and 7% after the fourth or more. After KD therapy for 1, 3, 6, and 12 mo, the seizure-free rates were 14%, 32.5%, 30.7%, and 19.3%, respectively; KD efficacy (>50% reduction in seizure frequency) were 57.9%, 76.3%, 59.6%, and 43%, respectively; the retention rates were 97.4%, 93%, 71.9%, and 46.5%, respectively; and the rates of adverse events were 25.2%, 19.9%, 11%, and 5.7%, respectively.Conclusions: Real-world, multicenter data analysis showed that the KD is effective for patients with DS and has a low incidence of side effects.& COPY; 2023 Published by Elsevier Inc."

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