Procalcitonin/Albumin Ratio Predicts the Outcome After Severe Traumatic Brain Injury: A Propensity Score-Matched Analysis

作者全名："Sun, Mingjiang; Gu, Lingui; Li, Yuanyou; Luo, Fushu; Tao, Yihao; Shen, Weiwei; Xie, Zongyi"

作者地址："[Sun, Mingjiang; Tao, Yihao; Xie, Zongyi] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Sun, Mingjiang] Capital Med Univ, Beijing Tiantan Hosp, Beijing Neurosurg Inst, Beijing, Peoples R China; [Gu, Lingui] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Ctr Malignant Brain Tumors, Natl Glioma Multidisciplinary Team Alliance,Dept N, Beijing, Peoples R China; [Li, Yuanyou] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Peoples R China; [Luo, Fushu] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China; [Shen, Weiwei] Chongqing Med & Pharmaceut Coll, Affiliated Hosp 1, Dept Endocrinol, Chongqing, Peoples R China"

通信作者："Xie, ZY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：NEUROCRITICAL CARE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001040852000001

JCR分区：Q2

影响因子：3.1

年份：2023

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期号：　

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结束页：　

文献类型：Article; Early Access

关键词：Outcome; Procalcitonin; albumin ratio; Propensity score matching; Severe traumatic brain injury

摘要："BackgroundThe procalcitonin/albumin ratio (PAR), a novel inflammation-based index, has been reported to predict the prognosis following cardiopulmonary bypass surgery and bacterial infection. However, whether PAR can predict the outcome of patients with severe traumatic brain injury (STBI) has not been fully elucidated. This study aimed to investigate the relationship between serum PAR levels and prognosis at 6 months after STBI.MethodsWe retrospectively enrolled 129 patients diagnosed with STBI and collected relevant clinical and laboratory data. Logistic regression analysis was used to estimate the association of PAR with the prognosis of STBI. The receiver operating characteristics curve was performed to examine the predictive use of PAR for prognosis. Propensity score matching (PSM) analysis was also performed to improve the reliability of the results. The primary outcome measures were expressed as a score on the modified Rankin Scale at 6 months.ResultsThe unfavorable prognosis group had advanced age, lower Glasgow Coma Scale score, higher rate of cerebral hernia and intracranial infection, higher neutrophil/lymphocyte ratio (NLR) and C-reactive protein/albumin ratio (CAR), elevated PAR, and higher rate of pneumonia. Multivariate analysis showed that PAR (before PSM: odds ratio 3.473, 95% confidence interval 2.983-4.043, P < 0.001; after PSM: odds ratio 5.358, 95% confidence interval 3.689-6.491, P < 0.001) was independently associated with unfavorable outcome. The area under the curve of the PAR for predicting an unfavorable outcome was higher than that of the CAR and NLR.ConclusionsThe PAR might be a novel independent risk factor of the outcome after STBI. Moreover, PAR was a better biomarker in predicting the outcome of patients with STBI than CAR and NLR."

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